Project Grant RC2DK142620
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Broad Institute, Inc. $1,647,485 on September 19, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct massive-scale genomic risk assessment across monogenic and common forms of diabetes. The award will support analysis of the largest dataset of rare variation linked to diabetes phenotyping, comprising more than 1.1 million participants (33 percent...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $258,031 on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to employ long-read RNA sequencing to comprehensively characterize alternative splicing events in kidney tissue and their role in chronic kidney disease. The recipient will conduct bulk kidney tissue analysis to identify novel isoforms and compare isoform expression between...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Children's Hospital of Philadelphia Research Institute $1.868 million on June 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct integrative proteomics, metabolomics, and genomics analysis identifying mechanistic pathways of adverse outcomes in pediatric chronic kidney disease. The research leverages stored biosamples and existing data from over 1,100...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $1,542,009 under Project Grant R01DK140340 on September 9, 2025, to map the gene regulatory architecture of pancreatic islet cell types and their contribution to diabetes pathogenesis and progression. The funded work integrates single-cell gene expression and accessible chromatin data from publicly available and newly generated sources to create the largest comprehensive map of islet...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of North Carolina at Chapel Hill $1,009,330 on June 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and validate DNA and metabolomic biomarkers of dietary intake, specifically distinguishing polyphenol-rich diets from diets high in processed foods. The funded work addresses limitations in dietary assessment for nutritional epidemiology....
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $691,758 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate DCLK1 isoform switching and its role in proximal tubule injury during kidney disease progression. The award funds basic research to understand how DCLK1 regulates inflammation and DNA damage response pathways in injured proximal tubule cells, which...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $812,862 on June 12, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify novel biomarkers of early progressive kidney function decline in type 1 diabetes. The research will use urinary and plasma peptidomics—analysis of synthesized peptides and protein degradation fragments—to discover prognostic markers that predict diabetic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $792,019 on May 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to phenotype and predict ultrafiltration intolerance and guide transitions from continuous to intermittent kidney replacement therapy. The award funds research addressing hemodynamic complications that arise when critical-care patients transition from continuous kidney...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $789,828 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop theoretical models validated through experiments explaining the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). The project develops and validates tissue-mechanics models to predict how cholesterol crystals in the liver drive...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $698,501 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify gene-level interactions between host immunity and the intestinal microbiota that regulate inflammation in inflammatory bowel disease. The funded research combines microbiota analysis tools, host single-cell RNA sequencing, and machine learning methods to...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $1,000,650 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct multiomic analysis of African populations to identify novel genetic and environmental markers of cardiometabolic risk applicable to the U.S. population. The recipient will generate genomic, metabolomic, and proteomic data alongside detailed cardiometabolic phenotype measurements from geographically diverse African populations. The study aims to identify pathways and biomarkers correlating genetic variation, diet, environmental factors, and cardiometabolic phenotypes in both Africans and African Americans, focusing on how genetic variants common in sub-Saharan Africans due to their demographic history and environmental adaptation contribute to elevated cardiometabolic disease risk in people of African ancestry. The interdisciplinary team will develop high-dimensional multi-omic datasets and innovative integration approaches to identify genetic and environmental factors impacting cardiometabolic traits, with findings intended to support development of improved diagnostics and therapeutics effective across all ancestries. Work is performed in Philadelphia, Pennsylvania, with a period of performance extending from September 1, 2026, through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/28/26 |