Project Grant R829746010

This Project Grant award from the National Cancer Institute (NCI), under the federal Cancer Cause and Prevention Research program (CFDA 93.393), provides $577,529 to Health Research, Inc. to investigate the relationship between accelerated ribosomal DNA (rDNA) methylation age and early-onset prostate cancer in African American patients. The main objectives are to: 1) determine if African American prostate cancer patients exhibit higher rDNA methylation age at diagnosis compared to age-matched...

This $680,334 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) will support research to elucidate the molecular mechanisms and cellular players driving age-associated pro-tumoral myelopoiesis. The Icahn School of Medicine at Mount Sinai, the prime awardee, will conduct high-dimensional profiling of tumors from early-stage lung cancer patients, perform multi-omics phenotyping of myeloid cells and progenitors, and undertake complex bone...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $243,750 to the Sanford Burnham Prebys Medical Discovery Institute to conduct research on the impact of aging on the initiation and progression of pancreatic ductal adenocarcinoma (PDAC). The key objectives are to 1) examine how the aging stroma (tumor microenvironment) affects PDAC tumor growth and metastasis, and 2) investigate the influence of age on the intrinsic oncogenic potential of the...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $687,288 will fund a comparative analysis of somatic mutational processes across primate species with diverse lifespans. The primary awardee, the University of California, Berkeley, will collaborate with researchers at the University of Cambridge and Wellcome Sanger Institute to: Generate a comprehensive atlas of somatic mutation rates, signatures, and clonal dynamics across 10 tissue...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $115,411.00 to evaluate dynamic changes in aging-related clinical decline among older survivors with early-stage non-small cell lung cancer. The award to Weill Medical College of Cornell University aims to identify multilevel determinants, including social determinants of health, associated with disparities in clinical decline trajectories. This longitudinal study of over 89,000 lung...

The National Cancer Institute (NCI) awarded a $148,050 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to Weill Medical College of Cornell University. The grant supports research to dissect the mechanisms of APOBEC3 (A3) mutagenesis in lung cancer. Specifically, the project aims to identify the A3 family members responsible for lung cancer mutagenesis, evaluate surrogate measures of A3 mutagenesis, and explore how A3 enzymes regulate genome-destabilizing retroelements in...

This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to SRI International provides $401,125 in funding to quantify the association between genetic factors and radiation sensitivity in cancer patients. The research aims to identify germline genetic variants and gene expression patterns that contribute to individual differences in radiation response. The goal is to develop a predictive screening platform to optimize radiation dosing and mitigate...

This Project Grant award, totaling $158,365, was provided by the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) to the University of North Carolina at Chapel Hill to support research on understanding the impact of the NRF2 transcription factor on lung squamous cell carcinoma (LUSC) initiation and progression. The research focuses on developing a novel genetically-engineered mouse model to study how NRF2 activation affects LUSC incidence, tumor characteristics, gene expression,...

The National Cancer Institute (NCI) awarded a $224,099 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to the University of California, San Diego (UCSD) to develop a targeted colorectal cancer (CRC) screening strategy for adults aged 45-49. The key objectives are to: 1) characterize the acceptability and factors influencing CRC screening uptake in this newly eligible age group, and 2) evaluate the comparative effectiveness of an active outreach screening approach versus...

This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to The Trustees of Columbia University in the City of New York provides $2,775,137 to conduct research on the role of aging-related factors in the transformation of pre-leukemic conditions to acute myeloid leukemia (AML). The key objectives are to 1) establish how transcriptional deregulation, inflammatory signals, and stromal niche interactions promote clonal outgrowth of pre-leukemic...