This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to The Trustees of Columbia University in the City of New York provides $2,775,137 to conduct research on the role of aging-related factors in the transformation of pre-leukemic conditions to acute myeloid leukemia (AML). The key objectives are to 1) establish how transcriptional deregulation, inflammatory signals, and stromal niche interactions promote clonal outgrowth of pre-leukemic hematopoietic stem cells, leading to AML development, and 2) map the mutational and transcriptomic evolution of AML in the context of aging-associated intrinsic and microenvironmental factors. The research will integrate data from patient samples, mouse models, and single-cell analyses to identify new regulatory pathways and therapeutic targets for preventing AML progression from pre-cursor conditions. The project also includes sub-awards to Weill Cornell Medical College and Albert Einstein College of Medicine to provide specialized expertise and services in areas such as bone organoid studies, imaging mass cytometry, and longitudinal sample analysis.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.8m | 9/3/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
3GG01971301S | Weill Medical College Of Cornell University | Project Grant P01CA285250 | $19.6k | 3/11/25 | |
1GG01971306S | Albert Einstein College Of Medicine | Project Grant P01CA285250 | $627.5k | 2/20/25 | |
2GG01971304COREBS | Weill Medical College Of Cornell University | Project Grant P01CA285250 | $125.2k | 2/11/25 |