This federal Project Grant award for $506,404.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The award supports research by the University of Pennsylvania to investigate mechanisms of local and global epigenetic changes that drive senescence and aging-associated phenotypes. Key focus areas include: 1) understanding how enhancers are rewired during senescence and aging, 2) investigating how cryptic transcription is initiated within genes...
This Project Grant award of $158,918 from the National Institute on Aging (CFDA 93.866 Aging Research) will support Vanderbilt University's research into the effects of lifestyle on immune function and molecular aging across different populations. The study will use a multi-omic approach to characterize age-related changes in gene expression, DNA methylation, and clonal hematopoiesis in subsistence-level groups like the Tsimane, Turkana, and Orang Asli, as well as urban populations in the U.S....
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $105,952 to Weill Medical College of Cornell University to identify and characterize clonal expansions in aging and aging-related diseases. The key objectives are to: (1) develop tools to identify candidate somatic variants at scale from publicly available data, and (2) apply novel technologies that map genotype to epigenetic phenotype in single cells to analyze multiple tissues from...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $719,873 to The Trustees of Columbia University in the City of New York to conduct research on the role of epigenetic deregulation in osteoblasts and its promotion of age-related clonality in hematopoietic cells. The overarching goal is to delineate how epigenetically modified stromal cells and osteoblasts in the bone marrow can support the transformation of IDH1/2-mutant hematopoietic...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $430,956 Project Grant to Duke University to identify novel clinical and 'omic risk factors, including telomere length, mitochondrial copy number, and clonal hematopoiesis, for organ dysfunction and early mortality in sickle cell disease (SCD). The project also aims to discover proteomic and glycoproteomic biomarkers for premature mortality in SCD. This research is expected to yield...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $255,420 to The Trustees of the University of Pennsylvania to conduct research aimed at understanding the mechanisms that balance cellular repair and regeneration in aging and disease. The central hypothesis is that the loss of coordination between autophagy (cellular repair) and Hedgehog-dependent proliferation leads to accelerated cellular aging, which may predispose individuals to early-onset...
This $101,925 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) will support research by Weill Medical College of Cornell University to investigate the role of the propionate metabolism pathway in cell senescence and aging-related diseases. The key objectives include: Continuing to examine the function of methylmalonic acid (MMA) in cell senescence and aging-associated pulmonary fibrosis. Characterizing a novel role for propionyl-CoA (P-CoA) in lipid droplet...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,358,537 provides funding from September 1, 2024 to August 31, 2027 to the University of Pittsburgh to conduct research on the relationship between epigenetic aging, cognitive function, brain health, and Alzheimer's disease biomarkers, and how exercise impacts these factors in non-cognitively impaired older adults. The overarching goal is to elucidate the biological underpinnings of...
The National Institute on Aging (NIA) awarded a $331,270 Project Grant (CFDA 93.866 - Aging Research) to the University of Houston System to study the relationship between place, stress, and cognitive status among middle-aged and older Black men. The 2-year project, running from September 1, 2024 to August 31, 2026, aims to examine how residential environments and cumulative stress impact cognitive function and impairment in this population. The research will leverage resources from the Johns...