This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $3,865,458.00 to evaluate the relationship between physical function, geriatric assessment, and biological aging markers with clinical and quality of life outcomes among older adults with colorectal cancer. The project will recruit a prospective cohort of 462 colorectal cancer patients aged 70 and older to assess physical function, geriatric assessment, and biomarkers of aging prior to...
The Project Grant award with ID R01AG090337 is funded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The total funding amount is $639,740.00 with a performance period from December 15, 2024 to November 30, 2029. The grant aims to explore the role of the CD38 enzyme and CD8 tissue resident memory (TRM) cells in the development of chronic lung fibrosis following viral pneumonia, including COVID-19. The research seeks to understand the...
This $789,664 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a comprehensive study to characterize the effect of age on the cellular microenvironment of the human lung and peripheral blood. The Icahn School of Medicine at Mount Sinai will leverage single-cell RNA sequencing and spatial transcriptomics to model age-related changes in cell composition, gene expression, and cellular interactions. The goal is to uncover new therapeutic...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $235,026 to Washington State University to conduct research on how aging affects the interaction between airway distensibility and lung inflation, and the impact on maximal expiratory flow volume in elderly adults. The research will involve three specific aims: 1) Comparing the effect of deep inhalation on the maximal expiratory flow volume curve in young and elderly adults, 2)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $243,750 in funding to the Sanford Burnham Prebys Medical Discovery Institute to investigate the role of aging on the initiation and progression of pancreatic ductal adenocarcinoma (PDAC). The research aims to 1) examine how the aging stromal environment affects PDAC tumor growth and metastasis, and 2) evaluate the impact of age on the intrinsic oncogenic potential of the pancreas. This...
This $513,957 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Sloan-Kettering Institute for Cancer Research supports research to understand the cellular mechanisms regulating lymph node maintenance and homeostasis in aging. The study aims to determine the effects of aging on lymphatic endothelial cells (LECs) and the role of LEC NF-kB signaling in adult lymph node function. The researchers will leverage single-cell RNA sequencing and novel...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,978 to the University of Pittsburgh to conduct a longitudinal study investigating the relationship between socioeconomic disadvantage, accelerated epigenetic aging, and cognitive decline in midlife. The 5-year project aims to test the impact of timing and duration of exposure to individual and community-level socioeconomic disadvantage on cognitive function and change over a 10-16 year...
This $692,417 federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) will support research to elucidate and define accelerated cardiac aging in a diverse population of adolescent and young adult (AYA) cancer survivors. The award will leverage a cohort study called Project DANCES to investigate the incidence of accelerated cardiac aging in AYA cancer survivors, as well as identify predictors of this phenotype including the impact of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $943,540 to the Dana-Farber Cancer Institute (DFCI) to develop and evaluate a shared decision-making (SDM) toolkit for older breast cancer survivors on the use of surveillance mammography. The project aims to determine the effects of the SDM toolkit on mammography use, decision quality, and knowledge in breast cancer survivors aged 80 and older, where median life expectancy is...
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund a research initiative led by Dr. Peter Abadir at Johns Hopkins University. The $198,976 award supports the development of an AI-driven system to assess physical and cognitive function in frail older adults, including those with Alzheimer's disease. The research aims to correlate these digital biosignals with molecular markers, enhancing understanding of frailty characteristics and...