This federal Project Grant award, totaling $774,930, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant aims to develop and validate a clinically representative mouse model of intervertebral disc degeneration-induced low back pain to facilitate the discovery of novel, non-addictive analgesics. The key products or services to be delivered under this 2-year R61 and 1-year R33 award include: 1) optimizing a cross-breeding protocol to reproduce the behavioral, radiographic, and cellular/molecular characteristics of clinical discogenic low back pain using an inducible, disc-specific SPARC deletion model; 2) validating the behavioral phenotype of the model and determining its responsiveness to pharmacological interventions like morphine, pregabalin, and ibuprofen; and 3) independent replication of the validated model at the University of New England. This research aims to provide a preclinical model that better represents the human condition of discogenic low back pain, enabling the discovery and validation of new non-addictive pain therapeutics.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $774.9k | 9/18/24 |