This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $605,253 to The Trustees of the University of Pennsylvania to investigate the mechanical crosstalk between the intervertebral disc and adjacent facet joints during spinal degeneration and repair. The research aims to characterize the progression of facet osteoarthritis following disc degeneration, assess differences in disc-facet pathobiology between males and females, and determine if restoring disc mechanical function can mitigate the advancement of facet osteoarthritis. The study will utilize animal models and human cadaveric tissues, with a focus on assessing inflammation, innervation, and immune cell infiltration as indicators of pain and biological dysfunction. The findings are expected to contribute to the development of advanced diagnostics and new targets for tissue engineering and regenerative medicine strategies to address spinal degeneration.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $605.3k | 9/25/24 |