Project Grant R61HL180352
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $185,578 to Vanderbilt University Medical Center to conduct the "MODE OF VENTILATION DURING CRITICAL ILLNESS AT MULTIPLE CENTERS (MODEM)" trial. The trial is a 4,785-patient randomized cluster-crossover study that aims to understand the effects of different mechanical ventilation modes on clinical outcomes for critically ill adult patients. The award...
- The federal Project Grant award of $731,827 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting research conducted by the J. David Gladstone Institutes in San Francisco, CA to investigate the mechanisms of oxygen toxicity. The key objectives include: 1) testing whether specific molecular pathways (diphthamide synthesis, de novo purine synthesis, and mitochondrial electron transport chain) are necessary and sufficient for impaired cell...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $185,720.00 to Vanderbilt University Medical Center (VUMC) to conduct a randomized clinical trial investigating the use of sedation-only versus sedation with neuromuscular blockade for emergency tracheal intubation of critically ill adults. The primary aim is to evaluate whether the sedation-only approach can prevent hypoxemia, which more than doubles the...
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $186,408 to the University of Washington to develop robust models that identify patients at high risk for persistent hypoxemic respiratory failure (HRF). The goal is to improve the ability to distinguish patients with persistent HRF early, which is critical for enrolling the highest-risk patients in clinical trials for new HRF...
- This federal Project Grant award of $738,154 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to develop a novel mortality risk prediction model to accurately assess mortality risk for ICU patients across all patient groups. The key objectives are to: (1) identify mechanisms of systematic measurement error in commonly used ICU mortality risk prediction models, and (2) develop an accurate ICU mortality risk prediction model. The project will...
- This federal Project Grant award, valued at $272,226.00, was granted by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The project aims to determine how clinician and scheduling characteristics impact patient outcomes, and explore the moderating effect of patient characteristics on these relationships, for mechanically ventilated adults in intensive care units. The project will conduct a novel secondary analysis utilizing a unique...
- This federal Project Grant award of $159,624.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Vanderbilt University Medical Center (VUMC) to investigate the role of hypoxia-inducible factor (HIF) in promoting alveolar regeneration and functional lung repair for patients with idiopathic pulmonary fibrosis (IPF) and other chronic lung diseases. The research aims to explore how modulating upstream disease mechanisms,...
- This federal Project Grant award of $430,606 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to create a new Pediatric Cardiorespiratory Research Training Program at Vanderbilt University Medical Center (VUMC). The goal is to provide 2-3 years of highly rigorous research training for pediatrics fellows and PhD scientists to facilitate their transition to tenure-track faculty positions as clinician-scientists. The program will support up to 2...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $748,970 in funding to The Trustees of the University of Pennsylvania to conduct research aimed at better understanding the implementation of evidence-based treatments for mechanically ventilated patients in intensive care units (ICUs). The key research objectives are to: 1) quantify the penetration over time of four evidence-based treatments (sedation...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $761,599.00 to Trustees of Boston University, doing business as Boston University Medical Campus, to conduct research on quantifying uncertainty to inform time-limited trials of invasive mechanical ventilation. The research aims to fill critical knowledge gaps around clinicians' ability to recognize prognostic uncertainty, optimal durations for time-limited trials,...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $874,997 to Vanderbilt University Medical Center (VUMC) to conduct a randomized trial evaluating personalized oxygen therapy for critically ill, mechanically ventilated adults. The project aims to develop and validate a statistical model that can predict the optimal oxygen saturation target for individual patients to reduce mortality, compared to usual care. This builds on prior research by the investigators demonstrating potential mortality benefits of a personalized approach versus a one-size-fits-all oxygen target. The key next step is a prospective evaluation to determine if using the personalized oxygen targets decreases mortality for this critical patient population. The award period runs from September 15, 2025 to August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $875.0k | 9/10/25 |