Project Grant K23HL181100
- The federal Project Grant award of $180,936 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a research project titled "Building a Sedation Minimization Culture" at the University of Colorado-Denver. The project aims to 1) understand how individual ICU staff characteristics and their shared assumptions, values, and beliefs shape their collective approaches to sedation, and 2) promote sedation minimization in the ICU by...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $874,997 to Vanderbilt University Medical Center (VUMC) to conduct a randomized trial evaluating personalized oxygen therapy for critically ill, mechanically ventilated adults. The project aims to develop and validate a statistical model that can predict the optimal oxygen saturation target for individual patients to reduce mortality, compared to usual care....
- This federal Project Grant award, valued at $272,226.00, was granted by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The project aims to determine how clinician and scheduling characteristics impact patient outcomes, and explore the moderating effect of patient characteristics on these relationships, for mechanically ventilated adults in intensive care units. The project will conduct a novel secondary analysis utilizing a unique...
- This federal Project Grant, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to assess the timing and risk of developing Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) and sepsis in children following congenital heart defect (CHD) surgery. The $271,938 award to Vanderbilt University Medical Center (VUMC) will fund a deeper analysis of institutional databases to understand how this syndrome...
- This Project Grant award of $178,846.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to optimize ventilator management for patients with acute respiratory distress syndrome (ARDS) who require extracorporeal membrane oxygenation (ECMO) support. The primary goal is to determine if personalized positive end-expiratory pressure (PEEP) settings guided by esophageal manometry can reduce ventilator-induced lung injury (VILI), as measured by...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $748,970 in funding to The Trustees of the University of Pennsylvania to conduct research aimed at better understanding the implementation of evidence-based treatments for mechanically ventilated patients in intensive care units (ICUs). The key research objectives are to: 1) quantify the penetration over time of four evidence-based treatments (sedation...
- The University of Texas Southwestern Medical Center received a $685,724 project grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct a multi-center observational study on the association between ventilation and cardiac arrest outcomes. The study will leverage data from a large clinical trial database to analyze ventilation metrics using a machine learning algorithm developed to measure ventilation during continuous chest...
- This federal Project Grant award of $430,606 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to create a new Pediatric Cardiorespiratory Research Training Program at Vanderbilt University Medical Center (VUMC). The goal is to provide 2-3 years of highly rigorous research training for pediatrics fellows and PhD scientists to facilitate their transition to tenure-track faculty positions as clinician-scientists. The program will support up to 2...
- This federal Project Grant award of $738,154 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to develop a novel mortality risk prediction model to accurately assess mortality risk for ICU patients across all patient groups. The key objectives are to: (1) identify mechanisms of systematic measurement error in commonly used ICU mortality risk prediction models, and (2) develop an accurate ICU mortality risk prediction model. The project will...
- This $1,380,474 federal Project Grant awarded on September 24, 2025 by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to improve the care of patients with acute heart and lung diseases. The University of Michigan will develop data-driven models to support improved decision-making for intensive care unit (ICU) triage and inpatient bed assignment. The project will identify determinants of triage and bed assignment, develop a clinical decision...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $185,720.00 to Vanderbilt University Medical Center (VUMC) to conduct a randomized clinical trial investigating the use of sedation-only versus sedation with neuromuscular blockade for emergency tracheal intubation of critically ill adults. The primary aim is to evaluate whether the sedation-only approach can prevent hypoxemia, which more than doubles the risk of death in these patients. The funding supports VUMC's efforts to develop expertise in pragmatic trial design, exception from informed consent processes, and analysis of long-term functional and psychological outcomes after critical illness. This award aligns with the Cardiovascular Diseases Research program's goals of advancing basic, translational, clinical, and population science research to improve heart and vascular health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $185.7k | 7/30/25 |