Project Grant R01HL180743
Award Date 8/15/25
Completion Date 5/31/29
Dollars Obligated $749K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $761,599.00 to Trustees of Boston University, doing business as Boston University Medical Campus, to conduct research on quantifying uncertainty to inform time-limited trials of invasive mechanical ventilation. The research aims to fill critical knowledge gaps around clinicians' ability to recognize prognostic uncertainty, optimal durations for time-limited trials,...
- This federal Project Grant award, valued at $272,226.00, was granted by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The project aims to determine how clinician and scheduling characteristics impact patient outcomes, and explore the moderating effect of patient characteristics on these relationships, for mechanically ventilated adults in intensive care units. The project will conduct a novel secondary analysis utilizing a unique...
- The federal Project Grant award of $180,936 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a research project titled "Building a Sedation Minimization Culture" at the University of Colorado-Denver. The project aims to 1) understand how individual ICU staff characteristics and their shared assumptions, values, and beliefs shape their collective approaches to sedation, and 2) promote sedation minimization in the ICU by...
- This Project Grant award of $178,846.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to optimize ventilator management for patients with acute respiratory distress syndrome (ARDS) who require extracorporeal membrane oxygenation (ECMO) support. The primary goal is to determine if personalized positive end-expiratory pressure (PEEP) settings guided by esophageal manometry can reduce ventilator-induced lung injury (VILI), as measured by...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $185,578 to Vanderbilt University Medical Center to conduct the "MODE OF VENTILATION DURING CRITICAL ILLNESS AT MULTIPLE CENTERS (MODEM)" trial. The trial is a 4,785-patient randomized cluster-crossover study that aims to understand the effects of different mechanical ventilation modes on clinical outcomes for critically ill adult patients. The award...
- The University of Texas Southwestern Medical Center received a $685,724 project grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct a multi-center observational study on the association between ventilation and cardiac arrest outcomes. The study will leverage data from a large clinical trial database to analyze ventilation metrics using a machine learning algorithm developed to measure ventilation during continuous chest...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $701,795 to The Trustees of the University of Pennsylvania to conduct research aimed at defining the cardinal functions of lung progenitors during regeneration. The 4-year project, which began in September 2025, utilizes a multi-modal approach including cell lineage tracing, single-cell analysis, histological spatial analysis, and cross-species comparison to...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $174,420 to The Trustees of the University of Pennsylvania to conduct research aimed at improving lung transplantation outcomes. The key objectives are to investigate the impact of centralizing deceased organ donor management at specialized Donor Care Units (DCUs) and assess the consequences for diverse stakeholders in the national donation and transplantation...
- This Project Grant award of $147,486 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to investigate the role of inflammatory signaling in the migration and function of ectopic KRT5+ cells during severe respiratory viral injuries. The research will assess whether canonical NF-kB signaling is necessary for the expansion and migration of these ectopic cells, which have been associated with the development of pulmonary fibrosis following viral...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $754,729 to the University of Pittsburgh to investigate the mechanisms by which respiratory viral infections, including COVID-19, can lead to persistent lung inflammation and damage. The research aims to understand how viral antigen persistence in pulmonary endothelial cells drives chronic activation of CD8+ T cells, leading to long-term pulmonary sequelae. The...