This Project Grant award of $126,099.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research conducted by the University of California, San Francisco (UCSF) to investigate molecular phenotypes of frailty in lung transplantation. The principal investigator, an Associate Professor and lung transplant pulmonologist, will leverage existing research programs and collaborations to examine the heterogeneous pathobiology of pre- and...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,790,599.00 to the University of Pittsburgh to develop an automated frailty scoring system for assessing lung transplant candidates. The key objectives are to validate a "bio-geo-composition" concept as a biomarker for evaluating transplant fitness, and to create the "Pittsburgh Transplant Fitness Score" to...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $104,933 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Duke University. The grant supports research to determine the role of age-related clonal hematopoiesis of indeterminate potential (CHIP), an inflammatory biomarker, in cardiorespiratory fitness (CRF) and cardiometabolic responses to chronic exercise interventions. The project aims to evaluate whether CHIP is associated with baseline CRF and...
This $625,835 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to optimize aerobic fitness and functional response to exercise in older adults. The grant aims to test the efficacy of a combined high-intensity interval training (HIIT) and high-intensity resistance training (HIRT) approach to improve peak oxygen uptake (VO2peak) and physical function in patients eligible for cardiac rehabilitation, compared to standard...
This $2,803,961 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a collaborative research effort to investigate the mechanisms underlying primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD) in lung transplant recipients. The research team at Northwestern University will conduct four interrelated projects to better understand the role of lung-restricted alloantibodies,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program provides $1,564,220.00 to The Trustees of the University of Pennsylvania to develop an imaging-compatible pre-clinical ex vivo lung perfusion (EVLP) system. The goal is to obtain structural, functional, and metabolic biomarkers that can be used to non-invasively assess donor lung health and optimize EVLP parameters for reconditioning lungs prior...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is focused on testing the effectiveness and implementation of a home-based exercise intervention for individuals with an implantable cardioverter defibrillator (ICD). The primary goal is to determine if the Exercise-ICD (E-ICD) intervention can increase physical activity and improve related health outcomes in this patient population. The $728,781 award to the...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will support an investigation into the role of resistance exercise in the prevention and treatment of heart failure with preserved ejection fraction (HFpEF). The $117,789 award, with a period of performance from September 9, 2024 to August 31, 2026, will fund a research project led by Dr. McDonough at the University of Minnesota. The project...
This federal Project Grant award, valued at $2,241,717.00 and provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research aimed at defining the spatiotemporal profile and cellular heterogeneity of marginal zone B and B1 cell-specific protein (MZB1)+ B and plasma cell populations in the development of chronic rejection after lung transplantation. The overarching goal is to interrogate the mechanistic...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $799,354 to Northwestern University to conduct research on the role of necroptosis in primary graft dysfunction following lung transplantation. The project aims to comprehensively understand and target the necroptotic pathways in both the donor and recipient lungs to reduce the high incidence of primary graft dysfunction, which...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $452,181 to develop and test an 8-week exercise-based frailty intervention called XFIT for lung transplant candidates. The goal is to improve physical function and reduce frailty in this population at high risk for disability and mortality.
The award includes sub-grants to Columbia University ($352,181) and the University of Pennsylvania ($100,000) to serve as study sites for screening, recruiting, and delivering the XFIT intervention to lung transplant candidates. The sub-awardees will also contribute to the study conduct, data analysis, and dissemination. Additionally, the University of North Carolina at Chapel Hill will provide $75,000 in support for the exercise intervention development and evaluation. The award started on September 17, 2024 and is slated for completion by July 31, 2026.