The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $3,161,352 project grant (R01AG089069) to the University of Colorado-Denver. The 5-year grant, beginning on August 15, 2024, will fund a randomized controlled trial to investigate the molecular mechanisms underlying the heterogeneous effects of aerobic exercise training on peripheral and cerebrovascular function in adults of different ages and sexes. Key research activities include...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,545,208 to the Florida Institute for Human & Machine Cognition (IHMC) to conduct a 5-year research study on exercise response heterogeneity in older adults. The project aims to understand the mechanisms driving variability in older adults' responses to combined endurance and resistance training, with a focus on factors related to aging hallmarks like proteostasis, mitochondrial...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $1,294,013 to Mayo Clinic to conduct a randomized clinical trial examining the impact of biological mechanisms of aging on exercise response variability in older adults. The project aims to define the heterogeneity in physical function and insulin sensitivity outcomes in response to a 6-month resistance training intervention, with a focus on investigating the...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will support an investigation into the role of resistance exercise in the prevention and treatment of heart failure with preserved ejection fraction (HFpEF). The $117,789 award, with a period of performance from September 9, 2024 to August 31, 2026, will fund a research project led by Dr. McDonough at the University of Minnesota. The project...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $452,181 to develop and test an 8-week exercise-based frailty intervention called XFIT for lung transplant candidates. The goal is to improve physical function and reduce frailty in this population at high risk for disability and mortality. The award includes sub-grants to Columbia University ($352,181) and the University of Pennsylvania ($100,000) to serve as study...
This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Miami University supports research examining the interactive roles of cardiorespiratory fitness and adiposity on the recovery of impaired glucose and vascular control after a period of physical inactivity. The $422,894 award, effective from Apr 20, 2025 to Mar 31, 2028, will fund a study to investigate how existing health status impacts the recovery of impaired glucose...
This federal Project Grant award for $152,237 was provided by the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) program, to Virginia Polytechnic Institute & State University (Virginia Tech). The grant supports a 4-year research project to investigate neuromuscular adaptation to exercise in Alzheimer's disease (AD). The key objectives are to determine the neuromuscular adaptive response to endurance exercise training in AD mouse models before the onset of overt...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $654,500 to the University of Utah to conduct a sex-based study on the impact of chronic hypobaric hypoxia exposure (at high altitudes) on vulnerability to depression, with a focus on age effects. The key objectives are to evaluate how aging influences the effects of chronic hypoxia on inflammatory and bioenergetic processes, depression/anxiety symptoms, cognitive deficits, and treatment...