Project Grant R61EY036951
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded the University of Rochester a $1.31 million project grant effective July 1, 2025, through April 30, 2029, to investigate the pathogenic role of secretory phospholipase A2-IIA (PLA2G2A/sPLA2-IIA) in age-related macular degeneration (AMD). The research seeks to identify novel therapeutic targets for AMD, a leading cause of adult blindness with limited treatment options. The...
- Federal Grant Award Summary Rochester Institute of Technology received a $143,569 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) for the period July 1, 2025 through June 30, 2029. The award supports fundamental research to establish the multi-component phase diagram and statistical-thermodynamic molecular basis of concentrated, aqueous eye lens crystallin protein mixtures. This research directly addresses cataract disease, the leading cause of...
- Federal Project Grant Award Summary The University of Mississippi Medical Center received a $693,423 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 15, 2025, with an ultimate completion date of August 31, 2026. The grant funds the development of a multivalent antibody cocktail designed to prevent and treat bacterial endophthalmitis, an eye infection that can result from ocular surgery, trauma, or injections. The research...
- Federal Grant Award Summary The University of Oklahoma Health Sciences Center received a $1.43 million Project Grant from the National Eye Institute (CFDA 93.867 – Vision Research) awarded on September 1, 2025, with a completion date of August 31, 2027. This research grant funds investigation into bacterial pathogenic mechanisms underlying intraocular infections, specifically examining how ocular pathogens evade the intraocular immune response through polysaccharide capsule expression during the...
- Federal Grant Award Summary The University of Rochester received a $243,672 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded May 1, 2026, with completion targeted for August 31, 2028. This award funds research investigating the spatial and temporal dynamics of neural interactions underlying attention-related enhancement and suppression of visual processing. The research addresses a critical gap in understanding visuospatial attention...
- Federal Project Grant Award Summary New York University School of Medicine received a $546,439 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with an ultimate completion date of March 31, 2030. This award funds research to develop corneal stromal keratocyte modeling from human cornea organoids (HCOs) derived from induced pluripotent stem cells (iPSCs). The research aims to generate novel therapeutic cell sources and...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $421,136 Project Grant to the University of Maryland, College Park, effective August 1, 2025, through July 31, 2027, under the Vision Research program (CFDA 93.867). This award supports research into advanced wavefront shaping techniques designed to enable high-resolution fundus imaging in patients with ocular opacities—conditions affecting the cornea and lens that currently prevent effective posterior segment eye...
- Federal Grant Award Summary Wayne State University received a $586,258 Project Grant award from the National Eye Institute (CFDA 93.867 – Vision Research) effective July 1, 2025, through April 30, 2029. The award funds a research investigation titled "The Role of Eosinophils in Modulating the Corneal Response to Infection," which seeks to characterize how eosinophils—a type of innate immune cell—influence corneal inflammation and tissue damage during Pseudomonas aeruginosa-induced...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $1,431,260 to the Regents of the University of Michigan through the Vision Research program (CFDA 93.867) beginning August 1, 2025, with completion targeted for March 31, 2030. This project grant funds a Type 1 Effectiveness-Implementation hybrid randomized pragmatic clinical trial designed to test and validate a comprehensive, technology-based approach to glaucoma and eye disease screening in Federally Qualified Health...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded New York University School of Medicine a $673,747 Vision Research project grant (CFDA 93.867) commencing June 1, 2025, and concluding May 31, 2030, to develop advanced optical imaging technology for early detection of age-related macular degeneration (AMD). The research focuses on advancing visible-to-near-infrared spanning optical coherence tomography (OCT) to achieve half-micron axial resolution for retinal imaging,...
The University of Rochester received a $678,201 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded May 1, 2026, with a completion date of April 30, 2028. The grant supports the development of a novel topical ophthalmic antibiotic combination therapy consisting of polymyxin B/trimethoprim plus rifampin for treating bacterial keratitis (BK), an aggressive corneal infection responsible for over 2 million cases of blindness annually. The research addresses a critical gap in the ophthalmic antimicrobial pipeline, as no new classes of antimicrobials for eye infections have reached the market in approximately 15 years. The primary product deliverable is preclinical and translational development of the PT + rifampin combination, which preliminary screening and testing have demonstrated exhibits rapid bacterial killing, potent anti-biofilm activity, and complete eradication of Staphylococcus aureus and Pseudomonas aeruginosa infections in murine keratitis models. The drug combination has also demonstrated efficacy against multi-drug resistant clinical isolates, positioning it as a potential therapeutic superior to currently available treatments. This research directly supports NEI's mission to eliminate vision loss through innovative research to prevent and treat vision diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $678.2k | 5/5/26 |