Project Grant R61DA062821
- The National Institute on Drug Abuse awarded the University of Maryland, Baltimore $153,560 under the Drug Use and Addiction Research Programs (CFDA 93.279) on November 30, 2026, as a Project Grant (F32DA066191). The award funds research investigating how mitochondrial regulation influences structural plasticity and cocaine-seeking behavior in ventral hippocampus-nucleus accumbens projection neurons following prolonged abstinence from intravenous cocaine self-administration. The research...
- The National Institute on Drug Abuse awarded Vanderbilt University $236,664 on September 25, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how cocaine self-administration differentially alters neural encoding of drug and non-drug reinforcers in the nucleus accumbens. The research uses cellular-resolution imaging with microendoscopes to record single-cell neural activity in awake and behaving animals in response to both cocaine and sucrose, tracking how...
- The National Institute on Drug Abuse, a component of the Department of Health and Human Services, awarded Drexel University $684,123 on March 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of inflammasomes in the neurobehavioral and transcriptomic effects of cocaine exposure and HIV infection. The research addresses cocaine use disorder in people living with HIV, a population experiencing exacerbated risk for behavioral and cognitive deficits...
- The National Institute on Drug Abuse awarded Carnegie Mellon University $217,672 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to measure how addiction-associated genetic variants regulate gene expression across specific brain regions in response to opioids and cocaine. The research measures regulatory activity of candidate human addiction-associated genetic enhancers in the striatum, cortex, hippocampus, and amygdala of mice using in vivo massively parallel...
- The National Institute on Drug Abuse awarded the University of North Carolina at Chapel Hill $230,421 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how genetic background influences functional brain networks activated in response to cocaine exposure. The research uses whole-brain c-fos mapping and functional connectivity analysis in cleared brain tissue to identify patterns of neural activity in genetically heterogeneous mice exposed to cocaine....
- The National Institute on Drug Abuse awarded Icahn School of Medicine at Mount Sinai $720,691 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to design and develop blood-brain barrier-crossing conjugates that enable delivery of antisense oligonucleotides to the brain for treating cocaine use disorder. The project addresses the lack of FDA-approved medications for cocaine use disorder by leveraging recent advances in antisense oligonucleotide technologies to...
- The National Institute on Drug Abuse awarded The Medical University of South Carolina $211,680 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research investigating neurobiological mechanisms underlying reward-cue associations and relapse-like behavior in substance use disorders. The project, NPAS4+ Neuronal Ensembles: Mechanisms of Reward-Cue Associations and Relapse-Like Behavior, examines how neuronal activity in the nucleus accumbens...
- The National Institute on Drug Abuse awarded Psychogenics Inc. $398,947 on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct preclinical evaluation of two novel molecules as potential pharmacotherapies for cocaine use disorder. Psychogenics will evaluate the compounds' effects in behavioral models of cocaine self-administration and stress-induced reinstatement of drug-seeking behavior. The work includes testing both molecules' ability to reduce cocaine...
- The National Institute on Drug Abuse awarded $675,247 to Texas A&M University System Health Science Center on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how cocaine exposure disrupts cognitive flexibility through cholinergic dysregulation in the dorsomedial striatum. The project examines cocaine-induced alterations in medium spiny neurons and cholinergic interneurons, focusing on three specific aims. Aim 1 defines how enhanced inhibition...
- The National Institute on Drug Abuse awarded Drexel University $501,606 on April 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic research on hormonal and behavioral dysregulation following exposure to antiretrovirals and chronic cocaine use. The project uses preclinical models to investigate how antiretroviral therapy and pre-exposure prophylaxis interact with cocaine exposure to affect hormonal regulation and drug-seeking behavior in the context of HIV...
The National Institute on Drug Abuse awarded the University of Pittsburgh $351,314 on August 15, 2026, for imaging brain energy use in cocaine use disorder under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds positron emission tomography studies using [18F]BCPP-EF to measure mitochondrial complex I binding in the brains of treatment-seeking cocaine use disorder subjects compared to healthy controls. Phase 1 research will enroll 18 cocaine use disorder subjects and matched healthy controls, image their brains via PET, and follow the cocaine use disorder subjects for twelve weeks post-imaging to document relapse while providing financial incentives for abstinence. Phase 2 studies will expand the cohort to include an additional 32 cocaine use disorder and 32 healthy control subjects if Phase 1 milestones support the hypothesis of lower mitochondrial complex I binding in cocaine use disorder. The research examines how cocaine decreases mitochondrial electron transport chain activity, reducing adenosine triphosphate production and increasing reactive oxygen species generation, potentially driving relapse vulnerability. The studies will also characterize the relationship between oxidative phosphorylation and glucose utilization in cocaine use disorder brains. Work is performed in Pittsburgh, Pennsylvania. The period of performance extends through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/13/26 | ||
| Not listed | $351.3k | 8/11/26 |