Project Grant R21DA062185
Award Date 8/1/26
Completion Date 7/30/28
Dollars Obligated $218K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Pittsburgh, PA 15213, USA
Similar Awards
- The National Institute on Drug Abuse awarded the University of California, San Diego $169,832 on September 30, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research into the genetic basis of addiction-related behaviors. The project uses long-read sequencing technology to discover and characterize tandem repeats and structural variants in the genomes of N/NIH Heterogeneous Stock rats, genetic variants that conventional genome-wide association studies overlook....
- The National Institute on Drug Abuse awarded Boston Children's Hospital $800,131 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the functions and mechanisms of a molecularly defined prefrontal cortex neuron subtype in drug addiction. The research focuses on identifying and characterizing POU3F1-expressing layer 5 neurons in the prefrontal cortex and their role in regulating cocaine-seeking behavior. The work employs single-cell RNA sequencing...
- The National Institute on Drug Abuse awarded the University of Pittsburgh $700,254 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to examine how combined nicotine and opioid exposure alters the prefrontal cortex in opioid use disorder. The research addresses the gap between current OUD treatments and patient outcomes, particularly the role of nicotine dependence as a confounding factor. Between 80–90 percent of individuals with OUD smoke, yet smoking...
- The National Institute on Drug Abuse awarded the University of Pennsylvania $690,437 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of histone methyltransferase SETD2 in substance use disorders. The recipient will conduct research establishing that SETD2 inhibition attenuates cocaine self-administration through cell-type-specific regulation of alternative splicing and gene expression. The project applies locus-specific epigenetic...
- The National Institute on Drug Abuse awarded The Regents of the University of Colorado, doing business as University of Colorado-Denver, $1.266 million on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to establish and operate the NIDA Center of Excellence in Omics, Systems Genetics, and the Addictome. The center delivers training, data resources, and analytical tools enabling substance use disorder researchers to integrate data science, quantitative...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA), under its Drug Use and Addiction Research Programs (CFDA 93.279), awarded $877,500 to the University of California, San Diego for a two-year project (July 15, 2025 through June 30, 2027) investigating neurobiological mechanisms underlying cocaine use disorder (CUD) susceptibility. The project employs a novel polygenic prediction methodology called RATTACA to identify pre-existing cellular differences in gabaergic and...
- The National Institute on Drug Abuse awarded the University of North Carolina at Chapel Hill $427,625 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support mapping neural circuit and network contributions to addiction development. The project introduces a novel MRI-compatible cocaine self-administration system integrating calcium imaging with fMRI (termed SORDINO-fMRI) to enable simultaneous recording of neuronal activity in the medial prefrontal cortex and...
- The National Institute on Drug Abuse awarded Icahn School of Medicine at Mount Sinai $796,299 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct single chromatin fiber multiomic mapping in opioid use disorder brain tissue. The recipient will perform genome-wide profiling of chromatin organization directly from frontal and cingulate cortex nuclei obtained from donors with chronic opioid use disorder. The work charts nucleosomal array organization,...
- The National Institute on Drug Abuse awarded Drexel University $832,132 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate novel circuit mechanisms underlying opioid-induced dopamine elevations in the nucleus accumbens, operating beyond the canonical midbrain dopamine neuron pathway. The research explores how oxycodone enhances dopamine signals through local circuits in the nucleus accumbens, specifically examining the role of GABA and cholinergic...
- The National Institute on Drug Abuse awarded the University of North Carolina at Chapel Hill $230,421 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how genetic background influences functional brain networks activated in response to cocaine exposure. The research uses whole-brain c-fos mapping and functional connectivity analysis in cleared brain tissue to identify patterns of neural activity in genetically heterogeneous mice exposed to cocaine....