Project Grant R43DA061847
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA), under its Drug Use and Addiction Research Programs (CFDA 93.279), awarded $877,500 to the University of California, San Diego for a two-year project (July 15, 2025 through June 30, 2027) investigating neurobiological mechanisms underlying cocaine use disorder (CUD) susceptibility. The project employs a novel polygenic prediction methodology called RATTACA to identify pre-existing cellular differences in gabaergic and...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Texas Medical Branch at Galveston a Project Grant totaling $1,590,180 under the Drug Use and Addiction Research Programs (CFDA 93.279) to support discovery and development of GPR52 (G Protein-Coupled Receptor 52) ligand probes for treating cocaine use disorder (CUD). The five-year project, initiated September 1, 2025 and concluding May 31, 2030, focuses on identifying and characterizing...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Texas Medical Branch at Galveston a $880,000 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2025, with a completion date of June 30, 2027. This research project investigates GPR6 (G protein-coupled receptor 6) as a novel druggable target for treating cocaine use disorder (CUD). The research deliverables include characterization of GPR6 expression...
- Federal Project Grant Award Summary Funding Agency: National Institute on Drug Abuse (NIDA) Federal Grant Program: Drug Use and Addiction Research Programs (CFDA 93.279) Award Amount: $398,580 Award Date: June 15, 2026 Project Completion: May 31, 2027 Awardee: Doro Mind Inc. Doro Mind Inc. will develop a digital platform designed to address adverse effects resulting from non-disordered drug use in individuals with serious mental illness (SMI). The platform will incorporate two primary...
- Federal Grant Award Summary The University of California, Santa Barbara received a $645,966 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded June 15, 2026, with completion scheduled for March 31, 2031. This award supports preclinical medications development research to identify pharmacological interventions for psychostimulant use disorder (PUD), addressing the current lack of FDA-approved treatments. The research...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The University of Pennsylvania a $690,437 Project Grant effective May 1, 2026, through February 28, 2031, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research initiative investigates the role of histone methyltransferase SETD2 (SET Domain Containing 2) in substance use disorders through advanced epigenetic editing techniques. The project employs CRISPR/dCas9 locus-specific epigenetic...
- Federal Project Grant Award Summary Jillion Therapeutics Inc. received a Phase I Small Business Innovation Research (SBIR) Project Grant of $398,093 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective July 1, 2025, through June 30, 2027. The project will deliver research and development services focused on identifying therapeutic drug compounds to treat amphetamine use disorders through application of the company's...
- Federal Project Grant Award Summary This $1.23 million Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) funds neuroscience research investigating the integration of reinforcement learning and temporal processing mechanisms in the brain. Awarded to the University of California, Los Angeles (UCLA) effective July 1, 2025, through March 31, 2030, the project delivers experimental and computational research examining how...
- Federal Grant Award Summary Boston Children's Hospital received an $800,131 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded May 1, 2026, with completion scheduled for February 28, 2031. This award supports basic neuroscience research investigating the functions and mechanisms of a molecularly defined prefrontal cortex (PFC) neuron subtype in drug addiction. The research focuses on understanding how...
- Federal Grant Award Summary Drexel University received a $684,123 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a cross-model investigation examining the role of inflammasomes in the neurobehavioral and transcriptomic effects of cocaine exposure and human immunodeficiency virus (HIV) infection. The research addresses a critical knowledge gap regarding cocaine use disorder (CUD) comorbidity in people living with...
Psychogenics Inc. received a $398,947 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded June 15, 2026, with completion by May 31, 2027. The award funds preclinical drug discovery and evaluation services focused on developing pharmacotherapies for cocaine use disorder (CUD), an unmet medical need affecting approximately 0.5% of the U.S. population. Psychogenics will conduct behavioral studies evaluating two novel drug candidates with different mechanisms of action against cocaine-related and stress-induced drug-seeking behaviors using established animal models, including cocaine self-administration assays and stress-induced reinstatement protocols. The research deliverables include comprehensive preclinical testing to identify the most efficacious compound, evaluate its effects following single and repeated dosing, and assess selectivity for drug versus non-drug reinforcement through food-based behavioral assays. This data will inform advancement decisions and support eventual clinical development of a medication-based treatment option for CUD, addressing current treatment gaps where only psychological therapies are available despite their high costs and moderate effectiveness.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $398.9k | 6/9/26 |