Project Grant R61DA061825
Award Date
9/30/24
Completion Date
8/31/26
Dollars Obligated
$454K
Federal Agency
National Institute on Drug Abuse
Awardee
Drexel University (XF3XM9642N96)
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
MIDDLE CITY EAST, PA 19102, USA
Similar Awards
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $240,108 to Drexel University to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the dysregulation of reward-seeking behavior in the comorbid condition of HIV and cocaine use disorder (CUD). The research aims to use circuit-specific optogenetics and chemogenetics in mouse models to understand how HIV infection,...
This federal Project Grant award of $695,250, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at Howard University examining the role of endothelial injury and myeloid cell migration in the activation of inflammasomes in HIV infection and cocaine exposure. The research aims to characterize myeloid cell populations in the brains of HIV-transgenic mice under chronic cocaine treatment, evaluating the number,...
This federal Project Grant award of $180,606.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is funding research to investigate cocaine-induced proteomic adaptations in the nucleus accumbens region of the brain. The principal investigator will use a combination of behavioral, cellular/molecular, and bioinformatic approaches to characterize the cell-type and circuit-specific synaptic proteome changes in response to cocaine...
This federal Project Grant award for $263,119 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is focused on developing NLRP3 inhibitors to address HIV-associated neuroinflammation in cocaine use. The key objectives are to computationally design, synthesize, and screen novel analogues of a lead compound, AMS-17, to improve its biological activity and maintain low toxicity. The project involves in vitro and in vivo screening of...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,032,192 to Yale University to conduct research on the cell-type specific epigenomic effects of cannabis use in people living with HIV. The project aims to dissect the interactions between HIV infection and cannabis use, and identify potential druggable targets through comprehensive profiling of DNA methylation across different cell types. The...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...
This Project Grant award of $616,372 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to identify the role of transposable elements (TEs) in neuroinflammation and transcriptional/epigenetic dysfunction related to HIV-1 infection and cannabinoid use. The research will utilize single-cell/nuclei multiome data from a non-human primate model, post-mortem human brain tissues, and a human brain organoid model adapted...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will provide $234,000.00 to Georgetown University to conduct research on the effect of opioids on HIV transcription and latency. The key objectives are to understand the mechanisms by which opioids such as fentanyl, morphine, and methadone influence HIV proviral transcription in microglia and astrocytes, as well as to longitudinally measure and...
This Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $563,742 in funding to Old Dominion University (ODU) and its affiliated research foundation (Odurf) to conduct research on the role of dysregulated lipid metabolism in microglial activation and neurological symptoms associated with HIV and cocaine use. The key objectives are to determine the mechanisms by which HIV proteins and cocaine impact microglial lipid...