Project Grant R01DA061926

Award Date 9/30/24
Completion Date 7/31/29
Dollars Obligated $1M
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
New Haven, CT 06510, USA
Similar Awards
This $844,946 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research to investigate the epigenetic regulation of inflammasome activation and its modulation by cannabinoids during chronic SIV infection and cocaine use. Specifically, the research will: Examine the epigenetic mechanisms underlying cannabinoid-mediated reduction of cocaine-induced inflammasome activation in blood monocytes, brain, and...
This $1,790,186 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the mechanisms governing stress-immune interactions in people living with HIV (PLWH) and their associated distress and cannabis use disorder (CUD). The research project will use a cross-diagnostic approach to: Determine the hypothalamic-pituitary-adrenal (HPA) and immune response to acute stress among healthy controls, PLWH,...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will provide $441,000.00 over 5 years (from September 1, 2024 to July 31, 2029) to Yale University to conduct research on the molecular and cellular mechanisms linking cannabis use and major depressive disorder. The key objectives are to: 1) use single-cell genomics to identify transcriptomic and epigenomic changes in the brains of individuals with cannabis...
This $3,472,327 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to study the impact of poly-substance use on the crosstalk between microglia, astrocytes, and neurons that regulates HIV latency. Led by Case Western Reserve University, the project will utilize newly developed methods to derive authentic microglia, astrocytes, and neurons from induced pluripotent stem cells (iPSCs) to investigate...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $1,920,359 in funding to Father Flanagan's Boys' Home in Boys Town, NE to conduct research on the neurological impact of HIV and cannabis use. The primary objectives are to use next-generation magnetoencephalography (MEG) imaging to quantify cortical-subcortical brain dynamics in persons with HIV (PWH), and evaluate how cannabis use may modulate...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,470 to Drexel University to develop a new imaging pipeline to examine epigenetic spatial architecture in the central nervous system (CNS) of mice with HIV infection that self-administer cocaine. The goal is to understand the mechanisms by which HIV infection enhances the neurobehavioral effects of cocaine, with a focus on the role of histone...
This $714,783 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a comprehensive research initiative to investigate the intersection of HIV infection and opioid use on inflammasome activation, neuroinflammation, and neurotoxicity. The project will employ neuropathology, ex vivo, and in vitro methodologies to analyze brain tissue samples from persons with and without HIV, and with varying...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $3,717,777 in funding to the Icahn School of Medicine at Mount Sinai to investigate the impact of nicotine and HIV-1 infection on neuroinflammation and cognitive decline. The research aims to elucidate the role of the NLRP3 inflammasome in HIV-1-associated inflammation, with the goal of identifying potential therapeutic targets to address cognitive...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $360,100 to support research on the socio-structural determinants of cannabis and derived psychoactive cannabis product use and consequences among young adults. The research will be conducted by George Washington University, a private research university with extensive experience managing federal grants and contracts across scientific,...
This four-year, $4.6 million project grant from the National Institute on Drug Abuse will fund research at the University of Miami exploring the linkage between cannabis use, route of administration, cannabinoid content, and measures of cardiovascular disease (CVD) risk in people living with HIV (PWH). Specifically, the principal investigator - an interventional cardiologist and physician scientist focused on HIV and CVD prevention - will collect comprehensive data on 300 PWH ages 18-60 to...

This Project Grant award for $1,032,192 was provided by the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279). The project aims to conduct a comprehensive, cell-type based epigenomic analysis to identify druggable genes for people living with HIV infection who also use cannabis. The research will involve profiling DNA methylation patterns across five different cell types isolated from peripheral blood mononuclear cells, alongside functional validation studies both in vivo and in vitro. The goal is to gain unprecedented insights into the immunomodulatory effects of cannabis use in the context of HIV infection, with the potential to uncover novel therapeutic strategies through targeted drug repositioning. The project will be led by Yale University, a highly regarded private research institution, and is scheduled to run from September 2024 through July 2029.

Generated 4/29/25, 3:47 AM