Project Grant R61AT013720
- The National Institutes of Health National Center for Complementary and Integrative Health awarded The University of Chicago $1,206,896 on August 12, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for Project Grant R01AT013753. The award funds research investigating exclusive metabolic niches as a strategy for precision microbiome manipulation. The work encompasses three aims: investigating the ecological function of exclusive metabolic...
- The National Center for Complementary and Integrative Health awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $592,063 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for mechanistic research into probiotic interactions with host diet, digestive metabolism, and the microbial system. The award funds investigation of two metabolic pathways by which Lactobacillus rhamnosus GG regulates gut...
- The National Institutes of Health National Center for Complementary and Integrative Health awarded The Leland Stanford Junior University $787,346 on April 13, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to restore key functions to the industrialized gut microbiome. The project characterizes microbial strains capable of fermenting microbiota-accessible carbohydrates (MACs) into short-chain fatty acids (SCFAs)—acetate, propionate, and...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $128,695 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The project investigates how gut-derived microbial metabolites regulate host energy metabolism, with focus on the mechanistic basis for cross-kingdom metabolic interactions relevant to...
- The National Institute of Biomedical Imaging and Bioengineering, part of the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $132,300 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of programmable probiotic biofilms as a living therapeutic platform to address dysbiosis-driven chronic...
- The National Center for Complementary and Integrative Health awarded University of California, Los Angeles $697,641 on August 15, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to conduct a randomized, double-blind, placebo-controlled mechanistic clinical study examining probiotic regulation of gut-microbiome-brain interactions in obesity and eating behaviors. The study treats 250 participants (200 with obesity, 50 controls without obesity)...
- The National Center for Complementary and Integrative Health awarded the University of California, San Diego $428,855 on April 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to develop computational and experimental approaches for identifying donor microbiota communities capable of stably engrafting in fecal microbiota transplantation (FMT) therapies. The research addresses a critical gap in predicting FMT outcomes by hypothesizing that...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $2.284 million on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on microbial interactions combating antibiotic-resistant bacteria (MI-CARB). The research employs a systems biology approach to understand pathogenesis of nosocomial infections caused by three pathogen groups: vancomycin-resistant enterococci (VRE),...
- Federal Grant Award Summary The University of Oregon received a $1,025,888 Project Grant award dated August 20, 2025, from the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The project, titled "Characterizing Individual Responsiveness to Exercise to Enable Engineering of Mitohormetic Probiotics," will be completed by July 31, 2027. The research aims to develop engineered...
- This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA 93.213 - Research and Training in Complementary and Integrative Health provides $451,000.00 in funding to The Trustees of Princeton University from September 2024 to August 2026. The objective is to characterize the secondary metabolomes of three Corynebacterial strains, including uncovering the small molecule products they use to compete with other microbes and interact with host cells....
The National Center for Complementary and Integrative Health, a component of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $546,000 on August 15, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for Project Grant R61AT013720. The award funds a two-phase investigation into precision probiotics engineered to support lactate metabolism and organ recovery in hospitalized patients. The R61 phase (Phase 1) will identify microbial genes, pathways, and strains in hospitalized patients that influence lactate metabolism, leveraging an existing biobank of rectal swabs from 1,550 hospitalized patients and a natural experiment created by the 2015–16 piperacillin-tazobactam shortage. The R33 phase (Phase 2) will develop a mechanistic probiotic strategy that protects engineered probiotics from concurrent antibiotic administration and augments host lactate metabolism through genetic engineering, targeting improved organ recovery and whole-person health outcomes. The research addresses a fundamental barrier to probiotic efficacy in hospitalized populations: broad-spectrum antibiotics administered concurrently with probiotics render traditional probiotic interventions ineffective. The team has identified that commonly-used anaerobic-targeting antibiotics worsen clinical outcomes and impair blood lactate clearance, and has demonstrated in murine models that orally administered probiotics with integrated lactate oxidase accelerate lactate clearance in lactic acidosis. Work is performed at the University of Michigan, Ann Arbor, Michigan. The award period extends through July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $546.0k | 8/18/26 |