Project Grant R01AT013744
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $128,695 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The project investigates how gut-derived microbial metabolites regulate host energy metabolism, with focus on the mechanistic basis for cross-kingdom metabolic interactions relevant to...
- The National Center for Complementary and Integrative Health awarded the University of California, San Diego $428,855 on April 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to develop computational and experimental approaches for identifying donor microbiota communities capable of stably engrafting in fecal microbiota transplantation (FMT) therapies. The research addresses a critical gap in predicting FMT outcomes by hypothesizing that...
- The National Center for Complementary and Integrative Health awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $592,063 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for mechanistic research into probiotic interactions with host diet, digestive metabolism, and the microbial system. The award funds investigation of two metabolic pathways by which Lactobacillus rhamnosus GG regulates gut...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded $413,972 to Oklahoma State University Center for Health Sciences on August 12, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds investigation of how early life stress triggers imbalances in gut bacterial genera, particularly Roseburia, and influences brain responses through...
- The National Institutes of Health National Center for Complementary and Integrative Health awarded The University of Chicago $1,206,896 on August 12, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for Project Grant R01AT013753. The award funds research investigating exclusive metabolic niches as a strategy for precision microbiome manipulation. The work encompasses three aims: investigating the ecological function of exclusive metabolic...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $205,000 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate synergistic effects of dietary interventions and probiotics on gut-lung immune modulation. The project explores how fiber-rich diet combined with intermittent fasting and probiotic strategies can attenuate sterile lung injury. Research Aim 1 tests...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Los Angeles $778,662 on April 6, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate genetic and gut microbial regulation of indole-3-propionic acid (IPA) in metabolic disease. The research examines how host genetic factors and gut bacterial metabolism jointly regulate plasma IPA levels and protect against obesity and type 2...
- This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA Program 93.213 - Research and Training in Complementary and Integrative Health, provides $506,000.00 in funding to the Scripps Research Institute in La Jolla, CA from September 13, 2024 to August 31, 2026. The award supports research to develop orally available recombinant peptidoglycan hydrolase therapeutics that can promote intestinal barrier function and protect against enteric...
- The National Institute of Allergy and Infectious Diseases awarded University of California, Los Angeles $459,971 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on mucosal IgA induction and spatiotemporal regulation of the microbiome. The research examines how immunoglobulin A antibodies produced in the intestine regulate the human gut microbiome in the absence of infection. The work investigates how IgA anchors bacterial...
- The National Institute of General Medical Sciences awarded Yale University $462,114 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate stress response mechanisms in beneficial gut bacteria, specifically how Bacteroides thetaiotaomicron uses carbon starvation as a regulatory signal to promote gut fitness factors. The research spans five years (through May 31, 2031) and focuses on establishing novel biological principles governing...
The National Center for Complementary and Integrative Health awarded University of California, Los Angeles $697,641 on August 15, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to conduct a randomized, double-blind, placebo-controlled mechanistic clinical study examining probiotic regulation of gut-microbiome-brain interactions in obesity and eating behaviors. The study treats 250 participants (200 with obesity, 50 controls without obesity) with a probiotic blend containing Akkermansia muciniphila and Bacteroides thetaiotamicron, which individually demonstrate known effects on tryptophan metabolism, glucagon-like-peptide (GLP-1) production, insulin sensitivity, weight, and waist circumference. Researchers will evaluate microbiome-gut-brain pathway responses using a 7 Tesla parallel transmit/receive coil capable of simultaneously imaging the brainstem and cortex at ultra-high field resolution. The award responds to funding opportunity NOT-AT-24-041. Performance occurs in Los Angeles, California through July 31, 2031. The project addresses unmet therapeutic needs in obesity treatment by clarifying underlying microbiome-gut-brain mechanisms, with potential to identify personalized, cost-effective, and implementable interventions that complement existing approaches and account for obesity's heterogeneous phenotypes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $697.6k | 8/18/26 |