Project Grant R01AT013330
- Grant Award Summary The National Center for Complementary and Integrative Health (NCCIH) awarded a $428,855 Project Grant to the University of California, San Diego effective April 1, 2026 through March 31, 2028, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds an integrated computational and experimental research initiative to develop novel approaches for precision microbiota transplantation therapies. The project addresses...
- Federal Grant Award Summary The Leland Stanford Junior University received a $434,090 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026, through March 31, 2028. This research initiative investigates the role of low-abundance microbial species in gut colonization resistance and their contribution to microbiome stability against Clostridioides difficile...
- This Project Grant, awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), provides $1,080,800 in federal funding to The Leland Stanford Junior University to advance translational microbiome science focused on the human small intestinal (SI) microbiota. Awarded September 5, 2025, with completion targeted for August 31, 2030, the grant supports the development of a comprehensive species atlas that characterizes the...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Leland Stanford Junior University a $423,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2028. The award supports research investigating how oxygen and bile acid processing influence the small intestinal microbiome and colonization resistance. The research will utilize non-invasive sampling...
- This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA 93.213 - Research and Training in Complementary and Integrative Health provides $451,000.00 in funding to The Trustees of Princeton University from September 2024 to August 2026. The objective is to characterize the secondary metabolomes of three Corynebacterial strains, including uncovering the small molecule products they use to compete with other microbes and interact with host cells....
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a project grant of $431,200 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on "Harnessing the Human Myeloid System to Improve Surgical Recovery." The research will be conducted through February 28, 2031, at Stanford's Palo Alto, California campus. This project delivers...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $532,500 through the Biomedical Research and Research Training program (CFDA 93.859) to University Enterprises, Inc. (doing business as Sacramento State Sponsored Research) for a three-year project spanning September 1, 2025, through August 31, 2028. The project investigates the function and evolution of bacterial strains within the human gut microbiota, specifically focusing on Paraclostridium...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $694,824 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded August 1, 2025, with completion scheduled for May 31, 2030. The research project, titled "Triangulating Mechanisms of Microbiome-Joint Crosstalk," investigates the interorgan communication between the gut microbiome and joints in osteoarthritis (OA) pathogenesis. The primary...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Harvard Medical School a Project Grant of $830,414 on August 13, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This research initiative, which extends through June 30, 2030, aims to identify and characterize microbiome-derived sulfated metabolites and elucidate their immunological effects. The project employs bioinformatic...
- Federal Grant Award Summary The University of California, San Diego received a $439,500 Project Grant from the National Center for Complementary and Integrative Health under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for the period April 1, 2026 through March 31, 2028. The award supports the development of advanced technologies and methodologies to enable high-resolution structural analysis of native polyketide synthase (PKS) megasynthases using...
The National Center for Complementary and Integrative Health (NCCIH) awarded a Project Grant of $787,346 to The Leland Stanford Junior University on April 13, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The research, conducted in Palo Alto, California, and scheduled for completion by December 31, 2030, addresses the restoration of key microbial functions in industrialized gut microbiomes. The project focuses on identifying and characterizing bacterial strains capable of fermenting microbiota-accessible carbohydrates (MACs) and producing short-chain fatty acids (SCFAs)—acetate, propionate, and butyrate—which are depleted in the U.S. population and linked to inflammatory diseases including diabetes, metabolic syndrome, and autoimmune disorders. The primary deliverables include the development of a comprehensive repository of bacterial strains with demonstrated capacity to ferment various dietary MACs and produce secondary bile acids and aryllactates. Aim 1 will characterize existing strain repositories and conduct isolations using novel protocols for whole-food intact, low-solubility fibers, with detailed characterization of SCFA profiles and functional metabolite production assays. Aim 2 will employ in vitro fermentation models to further evaluate strain functionality. The research builds on human dietary intervention findings demonstrating that reintroducing high levels of dietary MACs alone is insufficient to restore SCFA production in most healthy adults, suggesting that targeted replenishment of MAC-fermenting microbes may enhance metabolite production and reduce inflammatory markers in individuals with depleted microbiomes.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $787.3k | 4/17/26 |