Project Grant R61AG095927
- This federal Project Grant award of $113,683 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to characterize the determinants of cellular senescence and epigenetic dysregulation caused by tobacco smoke exposure in the lung. The research aims to: Determine the time- and age-dependent effects of cigarette smoke exposure on lung cellular senescence and associated epigenetic regulation in mouse models. Study the determinants of...
- This $789,664 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project titled "Dissecting the Cellular and Spatial Tissue Clock of the Human Lung and Peripheral Blood" at the Icahn School of Medicine at Mount Sinai. The project aims to leverage single-cell RNA sequencing and spatial transcriptomics to characterize the effect of age on the cellular microenvironment of the human lung and peripheral blood. The research will...
- The National Institute on Aging (NIA) awarded a $2,151,314 Project Grant to the University of Missouri System under the Aging Research program (CFDA 93.866) to conduct research on the effects of fine particulate matter (PM) exposure on small cerebrovascular inflammation and cognitive dysfunction. The 3-year project aims to investigate how PM exposure induces sex-specific inflammatory responses mediated by TNF-alpha in males and IL-6 in females, leading to cognitive impairment. The research...
- The federal Project Grant award of $108,978.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms underlying the age-related decline in the regenerative capacity of alveolar type 2 (AT2) cells in the lung. The principal investigator and research team at the Harvard T.H. Chan School of Public Health will conduct studies to determine whether elevated interferon gamma (IFNG) levels and changes in resident...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,740.00 to investigate the role of the CD38 enzyme in the development of chronic lung conditions following viral infections like COVID-19. The research aims to explore how targeting CD38 on CD8 tissue resident memory (TRM) cells could mitigate age-associated lung fibrosis after viral pneumonia. The award, effective December 15, 2024 through November 30, 2029, will support the lead researcher...
- This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), aims to elucidate the role of reverse electron transport (RET) in lung aging and idiopathic pulmonary fibrosis (IPF). The $460,283 award to the University of California, San Francisco (UCSF) supports a 2-year investigation focused on two key objectives: 1) conducting a detailed gene expression analysis to understand RET's influence on pro-fibrotic gene...
- This $3,264,260 Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 (Aging Research) aims to determine whether olfactory impairment caused by exposure to ambient fine particulate matter (PM2.5) pollution is a causal factor in the development of late-onset dementia, including Alzheimer's disease. The award will fund a comprehensive research project conducted by the University of Maryland, Baltimore to investigate the role of the cGAS/STING/IKK2/NF-κB inflammatory...
- The National Institute on Aging (NIA), under the federal Aging Research grant program (CFDA 93.866), awarded a $1,703,626 Project Grant to the University of North Dakota (UND) Division of Research & Economic Development. The grant, effective September 1, 2023 through August 31, 2026, will fund research to investigate the potential link between lung dysfunction and the progression of Alzheimer's disease (AD). Key objectives include: Characterizing the temporal changes in AD-related lung...
- This $463,625 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to better understand the effects of aging on the lung adenocarcinoma (LUAD) tumor microenvironment. The Icahn School of Medicine at Mount Sinai will use single-cell RNA sequencing and spatial analysis technologies to characterize age-related cellular and molecular changes in the LUAD tumor microenvironment. This research aims to uncover new therapeutic opportunities to modulate...
- This Project Grant from the National Institutes of Health's National Institute on Aging will fund research totaling $4,188,512 to the University of California, Davis from September 2022 through August 2025. The grant is part of the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research on aging processes and diseases affecting older populations. Specifically, the University of California, Davis will investigate the hypothesis that ultrafine particulate...
This federal Project Grant award from the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, provides $667,664 to the University of Pittsburgh to study the impacts of air pollution and cigarette smoke on lung aging. The project, running from August 2025 to July 2027, will utilize human organoid and precision cut lung slice models to define how particulate matter (PM2.5) and cigarette smoke exposure influence mitochondrial dysfunction and cellular senescence, two key components of the aging process. The research aims to identify new therapeutic targets for addressing accelerated lung aging and chronic obstructive pulmonary disease (COPD), a leading cause of death in the United States. This award is funded under the NIA's Aging Research program (CFDA 93.866), which supports comprehensive scientific investigations to understand the biological, clinical, and social aspects of aging.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $667.7k | 8/13/25 |