Project Grant K99HL171851
- This federal Project Grant award from the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, provides $667,664 to the University of Pittsburgh to study the impacts of air pollution and cigarette smoke on lung aging. The project, running from August 2025 to July 2027, will utilize human organoid and precision cut lung slice models to define how particulate matter (PM2.5) and cigarette smoke exposure influence mitochondrial dysfunction and cellular...
- The federal Project Grant award of $108,978.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms underlying the age-related decline in the regenerative capacity of alveolar type 2 (AT2) cells in the lung. The principal investigator and research team at the Harvard T.H. Chan School of Public Health will conduct studies to determine whether elevated interferon gamma (IFNG) levels and changes in resident...
- The University of Southern California (USC) Department of Contracts and Grants Division received a $413,958 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The purpose of this 1-year award, effective September 22, 2023, is to investigate the role of the protein PUMA in promoting cell death and inflammation in chronic obstructive pulmonary disease (COPD) caused by cigarette smoke exposure. The research aims...
- This Project Grant award of $762,867.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of the cofilin-1 protein in regulating mitochondrial function and quality control in airway epithelial cells. The research, conducted by The Johns Hopkins University, seeks to understand how the loss of cofilin-1 impacts mitochondrial dynamics and mitophagy, and how these processes contribute to airway epithelial dysfunction in...
- This $1,831,848 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate how early-life disruptions to gut microbiota colonization can remodel the development of lung immune and epithelial cells, contributing to chronic respiratory diseases. The research aims to identify the critical window and key microbial taxa required for establishing long-term lung homeostasis. Preliminary data indicates that...
- This Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund the development of novel computational methods to investigate the role of DNA methylation in the progression of Chronic Obstructive Pulmonary Disease (COPD). The $1,470,578 award, spanning from January 1, 2025 to December 31, 2028, will enable researchers at the University of Florida to assemble and analyze multi-omic data from large COPD...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,740.00 to investigate the role of the CD38 enzyme in the development of chronic lung conditions following viral infections like COVID-19. The research aims to explore how targeting CD38 on CD8 tissue resident memory (TRM) cells could mitigate age-associated lung fibrosis after viral pneumonia. The award, effective December 15, 2024 through November 30, 2029, will support the lead researcher...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), is supporting research to investigate the mechanisms by which exposure to certain chemicals, such as diacetyl and 2,3-pentanedione, can lead to the development of the devastating lung disease bronchiolitis obliterans. The $716,066 award to the University of Rochester aims to determine how these chemical exposures cause stress and...
- This federal Project Grant award, totaling $765,612.15, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research (CFDA 93.837) program. The award supports research to conduct a molecular analysis of airway secretory cells in the context of Chronic Obstructive Pulmonary Disease (COPD), the third leading cause of death in the U.S. and worldwide. The research, taking place at the Research Institute at Nationwide Children's Hospital in Columbus, Ohio,...
- This Project Grant award of $549,128 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a study to investigate the relationship between early-life factors, telomere length, and the development of subclinical atherosclerosis. The research team at The Research Foundation For The State University Of New York (RF SUNY) will measure telomere length from birth to young adulthood and assess its association with growth, air pollution exposure, and...
This federal Project Grant award of $113,683 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to characterize the determinants of cellular senescence and epigenetic dysregulation caused by tobacco smoke exposure in the lung. The research aims to: Determine the time- and age-dependent effects of cigarette smoke exposure on lung cellular senescence and associated epigenetic regulation in mouse models. Study the determinants of cellular senescence and epigenetic mediators in primary human small airway epithelial cells from healthy and COPD-affected individuals. The research is expected to identify gene targets and chromatin sites altered by cigarette smoking and associate them with COPD disease development. The award is for the period of September 1, 2025 to July 31, 2027 and is being provided to the University of Rochester, a leading research institution with extensive federal grant and contract experience.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $113.7k | 8/26/25 |