The federal Project Grant award R01AG090337, provided by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research into the cellular and molecular mechanisms underlying the development of chronic lung conditions following respiratory viral infections, including SARS-CoV-2. The $639,740 award, with a performance period from December 2024 to November 2029, will fund studies exploring the hypothesis that targeting the NAD+ ectoenzyme CD38 could mitigate...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will support a comprehensive study of the molecular mechanisms underlying pathological aging in the human brain and adipose tissue, as well as their inter-organ communication. The $1,394,250 award, active from August 2024 to July 2026, will enable researchers at the Icahn School of Medicine at Mount Sinai to leverage tissue transcriptomes to identify common gene...
This $528,011 Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the age-related loss of immune resilience during severe respiratory viral infections like COVID-19. The project, led by New York University School of Medicine, will use host transcriptomic approaches to identify immune response patterns that contribute to poor outcomes in older patients with respiratory viral infections. This includes analyzing lower airway and...
This $446,876 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a comprehensive spatial sequencing study of age-induced changes in the lung during influenza infection. Researchers at Northwestern University will utilize advanced techniques like single-cell RNA sequencing and spatial sequencing to generate a high-resolution atlas of young and aged lung tissue following...
The National Institute on Aging (NIA) awarded a $400,000 Project Grant (CFDA 93.866) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to develop methods for estimating intrinsic noise in single-cell sequencing data. The goal is to investigate the relationship between epigenetic, transcriptional, and splicing noise and cellular senescence, which is a key driver of aging. The project aims to address critical deficiencies...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai provides $842,114 to systematically investigate the molecular mechanisms of brain senescence in different molecular subtypes of Alzheimer's disease (AD). The project aims to identify and characterize senescent cells in major subtypes of AD using advanced single-cell multi-omics and spatial transcriptomics techniques. This comprehensive research initiative is...
This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $430,956 Project Grant to Duke University to identify novel clinical and 'omic risk factors, including telomere length, mitochondrial copy number, and clonal hematopoiesis, for organ dysfunction and early mortality in sickle cell disease (SCD). The project also aims to discover proteomic and glycoproteomic biomarkers for premature mortality in SCD. This research is expected to yield...
The National Institute on Aging (NIA), under the federal Aging Research grant program (CFDA 93.866), awarded a $1,703,626 Project Grant to the University of North Dakota (UND) Division of Research & Economic Development. The grant, effective September 1, 2023 through August 31, 2026, will fund research to investigate the potential link between lung dysfunction and the progression of Alzheimer's disease (AD). Key objectives include: Characterizing the temporal changes in AD-related lung...
This federal Project Grant award for $351,750 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to Yale University. The award will fund a 5-year research project to investigate the role of the protein NLRX1 in regulating immune system changes associated with aging. The primary goal is to elucidate the mechanisms by which decreases in NLRX1 levels contribute to age-related alterations in T cell function, including memory T cell expansion, reduced...