Project Grant R61AG094612
- The National Institute on Aging awarded the University of Southern California $586,743 on September 4, 2026, under the Aging Research program (CFDA 93.866) to develop the Gateway to American Aging Data (GAMA), a research infrastructure designed to accelerate life course research on how modifiable environmental exposures shape later-life health outcomes. GAMA will harmonize survey data across five nationally representative U.S. cohorts: the Panel Study of Income Dynamics (PSID), National...
- The National Institute on Aging awarded the University of Southern California $695,789 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop HGEA-NET, a multiscale computational model of the hippocampus that integrates cell type-specific gene expression and connectivity data to understand how progressive neurodegeneration of vulnerable neuronal populations leads to hippocampal network dysfunction and cognitive decline in Alzheimer's disease. The project builds on USC's...
- The National Institute on Aging awarded the University of Southern California $359,735 on September 1, 2026, under the Aging Research program (CFDA 93.866) for a Project Grant (R21AG091332) to develop generative artificial intelligence methods for interpretable Alzheimer's disease detection using denoising diffusion probabilistic models applied to neuroimaging. The project addresses the challenge of distinguishing brain changes attributable to Alzheimer's disease from normal age-related...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $690,898 on September 15, 2026, under the Aging Research program (CFDA 93.866) to conduct functional genetic analyses of healthspan in humans. The recipient will identify shared genetic architecture underlying age-related diseases and aging-related traits, experimentally validate the regulatory roles of healthspan-associated non-coding variants and their target genes, and elucidate molecular...
- The National Institute on Aging awarded the University of California Irvine $5,101,916 on July 1, 2026, under the Aging Research program (CFDA 93.866) to examine daily dynamics of social connection and their influence on physical and cognitive functioning across the adult lifespan. The research uses longitudinal daily diary datasets from the Midlife in the United States Study (MIDUS), including four waves of diary data across approximately 20 years (beginning in 2002, 2014, and 2023) and two...
- The National Institute on Aging awarded the University of California, Los Angeles $623,176 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on modifiable risk factors for Alzheimer's disease and related dementias among individuals aged 90 and older. The research triangulates evidence across four data sources—the LifeAfter90 Study (1,397 participants, all aged 90), the 90+ Study (1,630 participants, all aged 90), the Health and Retirement Study (3,359...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded the University of California Irvine $636,124 for Project Grant R01AG100345 on September 2, 2026, under the Aging Research program (CFDA 93.866). The award funds multi-omic characterization of molecular pathways driving vulnerability and resilience to Alzheimer's disease in the oldest-old population (age 90 and above). The research employs an integrative multi-omic approach including single-nucleus RNA and ATAC sequencing, spatial transcriptomics, and...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
The National Institute on Aging awarded the University of Southern California $710,296 on September 1, 2026, under the Aging Research program (CFDA 93.866) to expand research infrastructure for the Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium. The consortium integrates twin studies from five countries, focusing on adult development and aging, and has harmonized data from over 126,000 individuals to examine gene-environment interplay in aging, particularly regarding Alzheimer's disease and related dementias. The R61 phase, spanning through June 30, 2028, will establish centralized project management and data infrastructure, gather input from the research community to enhance scientific focus, and onboard new U.S. and international cohorts to expand genetic ancestries, environmental exposures, and national contexts available for analysis. The subsequent R33 phase will broaden the scientific focus to encompass functional and physical health outcomes, disseminate new statistical methods leveraging twin and molecular genetic data, provide funding for pilot projects, and mentor researchers in gene-environment interplay studies. Place of performance is Los Angeles, California. By the end of the funding period, IGEMS will have substantially advanced its research infrastructure, broadened the populations and environments included in its databases, and enhanced the capacity of the global research community to conduct innovative aging research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $710.3k | 8/24/26 |