Project Grant R01AG092662
- This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,221,450.00 to the University of California, Irvine to investigate the role of the retrosplenial cortex (RSC) in the progression of Alzheimer's disease (AD) pathogenesis in mice and humans. The key objectives are to: Define how neuronal hyperexcitability in the RSC contributes to the development of AD-related behavioral deficits in mice, and the underlying molecular mechanisms. Determine the...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Southern California provides $622,401 over 5 years starting January 1, 2025 to research causal models of brain biomarker changes leading to Alzheimer's disease and related dementias (ADRD). The project aims to: 1) fit novel deep learning models to predict ADRD pathology from diffusion MRI data, 2) generate individualized brain morphology prediction maps as "digital...
- The Project Grant award titled "ENHANCER-AAVS TO MONITOR AND RESTORE CELL-TYPE SELECTIVE INHIBITORY DEFICITS AND CIRCUIT DYSFUNCTION IN HUMANIZED ALZHEIMER'S DISEASE MODELS" was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The $1,459,072.00 award, granted to the J. David Gladstone Institutes, aims to monitor and manipulate inhibitory interneuron cell populations in mouse models to assess their contribution to...
- The National Institute on Aging (NIA) awarded a $4,276,054 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) on September 1, 2024. The project aims to develop mathematical models to quantitatively test and validate hypotheses regarding the selective vulnerability of genes, cells, and neural networks in mouse models of Alzheimer's disease (AD) tauopathy. The research will leverage two enabling...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,489,452 to the University of California, Irvine to investigate the circuit vulnerability of the lateral and medial entorhinal cortices in Alzheimer's disease tauopathy models. The research aims to characterize the activity of memory-supporting neural circuits compromised by Alzheimer's disease and identify neuronal subtypes impacted during disease progression. The project is...
- This $500,000 Project Grant was awarded on September 15, 2024 by the National Institute on Aging (CFDA 93.866 Aging Research program) to Neucyte Inc., a minority-owned small business specializing in advanced biomedical research and development. The funding will support the development of a miniaturized "mini-brain" microphysiological system (MPS) platform using Alzheimer's disease (AD) patient-derived cells. The goal is to create a scalable, reproducible in vitro brain model that can...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- The federal Project Grant award for "MULTISCALE MODELING AND EMPIRICAL STUDIES OF NORMAL AND PATHOLOGICAL BRAIN AGING" was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The $636,342 award will support research at Boston University Medical Campus from August 1, 2025 to April 30, 2030. The project aims to investigate the relationship between myelin dystrophy, synapse loss, and neuronal hyperexcitability in the aging brain, and how these...
- The National Institute on Aging (NIA) awarded a $438,625 Project Grant under the Aging Research program (CFDA 93.866) to the University of Texas at Austin. The grant, titled "Decoding the Heterogeneity of Interneuron Vulnerability in Aging and Alzheimer's Disease: An Ultraplex CLEM Approach," aims to better understand the selective vulnerability of hippocampal interneurons during aging and Alzheimer's disease. The research will use advanced microscopy techniques to characterize the...
This federal Project Grant award of $695,789.00 was provided by the National Institute on Aging (CFDA 93.866 Aging Research) to the University of Southern California (USC) to develop a new multiscale computational model of the hippocampus, called HGEA-NET. The goal is to investigate how the progressive degeneration of specific neuronal cell types in the hippocampus leads to network dysfunction and cognitive decline in Alzheimer's disease. The project will leverage USC's previous work creating a hippocampus gene expression atlas (HGEA) and expertise in multiscale computational modeling. The research will use spatial transcriptomics and viral connectomics approaches to study neurodegenerative changes in the hippocampus over the course of the 5-year project period from January 1, 2026 to December 31, 2030. This work aims to provide critical insights into the underlying mechanisms of Alzheimer's-related cognitive impairment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $695.8k | 12/29/25 |