This Project Grant award of $2,156,000.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports a research project to develop and validate non-invasive neuroimaging methods for quantifying brain oxygen availability, pH, and carbon dioxide levels. The goal is to better understand the relationship between cerebral blood flow, neuronal metabolic demands, and the regulation of waste products, in order to identify the underlying causes of brain...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $292,368 Project Grant under the Environmental Health (CFDA 93.113) federal grant program to the Regents of the University of Michigan. The grant, effective September 1, 2024 through March 31, 2026, will support research to "disentangle the drivers and dangers of toxic cyanobacteria biosynthetic heterogeneity in cyanobacterial harmful algal blooms (CyanoHABs)." The goal is to identify the effects of...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, supports research to further delineate the mitochondrial involvement in acute and chronic poisoning from organophosphates (OPs). The overarching goal is to investigate the mitochondrial contribution to neurological, cardiac and microcirculation sequelae, with a focus on novel biomarker development and therapy. The $821,373 award to The...
This $537,508 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to understand the role of endogenous zinc protoporphyrin (ZnPP) in intracerebral hemorrhage (ICH)-induced brain damage. The research aims to elucidate the mechanisms by which ICH triggers ZnPP formation and how ZnPP contributes to neurotoxicity, as well as evaluate...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $420,000.00 in funding to the Albert Einstein College of Medicine to investigate the molecular mechanisms of stress-induced mitochondrial damage. The research aims to identify novel pathways of mitochondrial dysfunction beyond the previously understood mitochondrial permeability transition pore (MPTP) mechanism, leveraging a...
The federal Project Grant award of $621,500 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The goal of the project is to develop new methods for combined molecular and ultrastructural imaging of neural cells and tissues using advanced nanoprobes and cathodoluminescent dyes. Specifically, the award will fund the development of (1) detergent-free...
This Project Grant award for $466,125.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The award supports a research project at New York University School of Medicine to identify and characterize key metabolic control mechanisms, with a focus on understanding cellular mechanisms for sensing pyrimidine levels and iron availability. The project will develop cell and mouse models to...
This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $222,750 to the University of Alabama at Birmingham (UAB) to define the molecular target of arsine gas-induced acute kidney injury and associated morbidity. The key objectives of this 2-year award are to: 1) characterize a mouse model of arsine toxicity, including dose- and time-dependent responses, biomarkers of acute kidney injury, and evaluation of multi-organ...
This Project Grant award of $704,313 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to advance a prognostic and monitoring biomarker of neutrophil-driven secondary brain injury in spontaneous intracerebral hemorrhage. The primary objective is to define and validate a standardized protocol to detect specific neutrophil biomarker levels as a potential prognostic and...