This Project Grant award from the National Institutes of Health (CFDA 93.310 - Trans-NIH Research Support) provides $222,750 to the University of Alabama at Birmingham to conduct research on defining the molecular target of arsine gas-induced acute kidney injury. The key objectives are to: Characterize a mouse model of arsine toxicity, including examining dose- and time-dependent responses, biomarkers of acute kidney injury, and potential multi-organ damage. This will help identify an optimal dose and timepoint for developing medical countermeasures. Define therapeutic targets of arsine toxicity, first screening NOD inhibitors using a phenylhydrazine mouse model, then testing the most effective NOD inhibitor against arsine-mediated kidney injury. The project aims to provide a fully characterized mouse model and a novel molecular target-based therapeutic drug as a medical countermeasure against the toxic effects of arsine gas exposure. The research was awarded on June 20, 2025 and is scheduled for completion by May 31, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $222.8k | 6/19/25 |