Project Grant R21ES036166

Award Date 6/20/25
Completion Date 5/31/27
Dollars Obligated $223K
Funding Federal Agency
Office of the Director
Federal Grant Program
93.310
Assistance Type
Project Grant
Place of Performance
Birmingham, AL 35294, USA
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This Project Grant award from the National Institutes of Health (CFDA 93.310 - Trans-NIH Research Support) provides $222,750 to the University of Alabama at Birmingham to conduct research on defining the molecular target of arsine gas-induced acute kidney injury. The key objectives are to:

  1. Characterize a mouse model of arsine toxicity, including examining dose- and time-dependent responses, biomarkers of acute kidney injury, and potential multi-organ damage. This will help identify an optimal dose and timepoint for developing medical countermeasures.

  2. Define therapeutic targets of arsine toxicity, first screening NOD inhibitors using a phenylhydrazine mouse model, then testing the most effective NOD inhibitor against arsine-mediated kidney injury.

The project aims to provide a fully characterized mouse model and a novel molecular target-based therapeutic drug as a medical countermeasure against the toxic effects of arsine gas exposure. The research was awarded on June 20, 2025 and is scheduled for completion by May 31, 2027.

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