Project Grant R56NS136328
Award Date
7/1/25
Completion Date
6/30/26
Dollars Obligated
$561K
Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
Similar Awards
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $596,937.00 to investigate the role of the FMRP protein in regulating mitochondrial function and energy metabolism in human neuron development. The research aims to elucidate the mechanisms by which FMRP and its target RACK1 regulate activity-dependent mitochondrial...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $460,940 to The University of Texas MD Anderson Cancer Center to investigate the impact of glioma-associated germline risk alleles on neurodevelopmental trajectories. The research aims to clarify the understudied area of preneoplastic priming in glioma cell-of-origin pools,...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $244,154 to Albert Einstein College of Medicine to investigate the regulation of presynaptic gene transcripts during synaptogenesis. The project aims to characterize the dynamics of the essential presynaptic active zone gene syd-2/liprin-alpha mRNA and identify novel candidates of mRNA...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,102,269 to the University of Illinois to conduct research aimed at understanding the relationship between precocious neuronal differentiation and early-onset neurodegeneration. The project will utilize the C. elegans model system to investigate how heterochronic gene mutations, such as lin-41 and lin-14, that cause precocious neuronal differentiation can subsequently lead to early-onset...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $479,397 to the University of North Carolina at Chapel Hill to conduct research on regenerative strategies targeting retinoic acid signaling in giant axonal neuropathy (GAN). The project aims to advance the understanding of the molecular and cellular processes that control axonal...
This $147,656 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the mechanisms contributing to neuronal excitability and pain in Fabry disease. The research project aims to identify the specific voltage-gated sodium channels dysregulated in Fabry disease sensory neurons, and determine whether heat-induced pain...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This federal Project Grant award of $364,448.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) focuses on investigating the neural functions of glycoprotein sialylation. The research aims to reveal sialylation-mediated mechanisms of glia-neuron coupling, elucidate the role of sialylation in promoting neuronal viability and resistance to oxidative stress, and characterize...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to investigate the role of region-specific reactive astrocyte factors in neuroinflammation. The $168,455 award to New York University School of Medicine, which began on January 15, 2025 and is scheduled to be completed by June 30, 2026, will fund...
This federal Project Grant award of $985,026 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the roles and mechanisms of epitranscriptomic regulation in the development and function of the mammalian nervous system, as well as the pathological consequences of disrupting these processes. The research program will utilize mouse models and human induced...