This $437,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support a study to conduct the first pooled in vivo screening of combination gene therapies for enhancing axonal regeneration after spinal cord injury. The study aims to systematically compare the effects of genetic knockouts and overexpression of candidate genes, both...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $653,309 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Children's Hospital Medical Center in Cincinnati, Ohio. The grant, titled "Systemic Enzyme Delivery by a Brain Targeted SapC-DOPS Nanocarrier for Treatment of Neuronopathic Gaucher Disease", aims to develop a novel enzyme replacement therapy (ERT) to treat neuronopathic Gaucher disease...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,006,322 to the University of California, San Diego (UCSD) to conduct research on understanding axon repair in the mammalian spinal cord. The key objectives are to refine and expand a regeneration classifier developed using patch-based single-cell RNA sequencing, investigate...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support the development and evaluation of a luminescence-based biosensor to non-invasively measure UBE3A activity in the brain. The $233,250 award to the University of North Carolina at Chapel Hill aims to improve the sensitivity of this biosensor and validate its use in primary cells and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, totaling $686,276, supports research to uncover the cellular mechanisms underlying Aicardi-Goutieres syndrome (AGS) and explore potential treatment approaches. The award will fund a collaborative effort between researchers at the University of Pittsburgh and the Children's Hospital of...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $460,940 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The University of Texas MD Anderson Cancer Center. This 2-year grant, effective June 1, 2025, will support research to investigate how glioma-associated germline risk alleles impact neurodevelopmental trajectories. Specifically, the research will leverage single-cell and bulk profiling...
This federal Project Grant award for $1,341,874.00 was issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research conducted by the University of California, San Francisco (UCSF) to elucidate the molecular mechanisms controlling dendrite development, function, degeneration, and regeneration. Key areas of focus include identifying the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to understand the mechanisms of glial cell response and facilitation of axon regeneration following nerve injury. The $218,068 award to The Children's Hospital of Philadelphia Research Institute will fund experiments to identify the specific glial cell...
This federal Project Grant award, valued at $676,388.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS), supports research under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The research aims to investigate how polarity signaling proteins, such as PARD6A and SIAH2, regulate chromatin compaction and nuclear organization during neuronal differentiation. The findings could lead to a better understanding...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,002,148 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Regents of the University of California, Berkeley. The grant supports research aimed at understanding the molecular, structural, and biochemical mechanisms that regulate the class III phosphoinositide 3-kinase (PI3K) complexes, which play a key role in controlling neuronal autophagy....