This $125,896 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support The Washington University's research to characterize the genetic and molecular pathways underlying Alzheimer's disease (AD) risk and resilience. The project aims to: 1) Dissect non-coding AD genetic risk through multi-omic molecular profiling of healthy and AD brain tissue; 2) Identify protective mechanisms in cognitively healthy, long-lived individuals including...
This federal Project Grant award, valued at $2,288,327 and provided by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research, supports research to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patient samples. The project aims to integrate polygenic risk scores for AD with multi-omic profiling of MCI patient-derived induced neurons (iNs) to better understand the early trajectory of...
This National Institute on Aging (NIA) Federal Project Grant Award (CFDA 93.866 Aging Research) provides $126,956.00 in funding to the University of California, San Diego (UCSD) from April 1, 2025 to February 28, 2027 to conduct research on generating new neurons in the aging adult brain. The goal is to identify the mechanisms and pathways of adult neurogenesis, with a focus on exploiting single-cell spatial transcriptomics to understand glia-to-neuron identity conversion. The research aims to...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides funding to the University of Illinois to investigate the roles of cellular senescence and blood-brain barrier dysfunction in mediating Alzheimer's disease progression induced by viral and bacterial pathogens. The $794,341 award runs from January 1, 2025 through December 31, 2029. The research leverages experimental mouse models, molecular characterization of endogenous retrovirus RNA...
This federal Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the role of senescent cells in brain aging and Alzheimer's disease and related dementias (ADRD). The $654,238 award, effective from September 15, 2024 to June 30, 2026, will enable researchers from the University of Texas Health Science Center at San Antonio (UTHSCSA) to generate spatial omics data from ADRD brains and mouse models,...
This federal Project Grant award, valued at $205,619 and awarded by the National Institute on Aging under CFDA 93.866 (Aging Research), will support research to map the landscape of the aged human brain in order to develop neurodegenerative disease models. The grant recipient, the University of Washington, will apply explainable artificial intelligence (XAI) methods to human brain data sets to identify molecular drivers of brain aging. The researchers will then manipulate these aging-related...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Miami is for a 2-year research project to investigate how the glial ion channel CLH-1 controls aging processes in the model organism C. elegans. The $1,055,313 award will fund experiments to establish the specific functions of the glial CLH-1 channel that influence lifespan and stress resistance, as well as identify the tissues and pathways regulated by this channel during...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $238,968 to the University of Maryland, Baltimore to develop a Bayesian computational system for modeling longitudinal functional microcircuits and examining microcircuit changes in a TDP-43 knockout mouse model. The goal is to advance the state-of-the-art in data analysis and modeling for longitudinal calcium imaging to better understand the dynamics of brain network changes in TDP-43 related...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,707,089 to Northwestern University to conduct research focused on synergistically enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD). The goal is to investigate whether simultaneously improving these three pathways can provide greater...
Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,102,269 to the University of Illinois to conduct research on the relationship between precocious neuronal differentiation and early-onset neurodegeneration. The project aims to identify novel common mechanisms in neurodegeneration, specifically investigating whether heterochronic perturbations that cause delayed neuronal differentiation can delay normal age-related neurodegeneration. The research will use C. elegans as a genetic model to study the role of the lin-41 gene, the homolog of the human TRIM71 gene associated with congenital hydrocephalus, in regulating the timing of neuronal differentiation and its impact on neurodegeneration. This 22-month project, with an award date of August 15, 2024 and ultimate completion date of April 30, 2026, seeks to advance the understanding of common neurodegenerative mechanisms and identify potential therapeutic targets.