This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports a research initiative led by the Washington University in St. Louis to investigate the molecular mechanisms underlying cerebral small vessel disease (CSVD) and vascular contributions to dementia (VCID). The $4,361,625 award, with a project period from September...
This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), aims to identify novel therapeutic targets for treating cerebral amyloid angiopathy (CAA) and its vascular contributions to Alzheimer's disease and related dementias (ADRD). The $5,949,022 award to The Jackson Laboratory, Emory University, Columbia University, and Rush University...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $10,847,672 in funding to the J. David Gladstone Institutes in San Francisco to conduct research on vascular-immune mechanisms underlying cerebral amyloid angiopathy (CAA) and Alzheimer's disease pathology. The research aims to elucidate the cellular and molecular processes that regulate the balance between vascular and parenchymal amyloid-beta accumulation, with a focus on the role of...
This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research examining the role of social determinants of health (SDOH) in the development of vascular cognitive impairment and dementia (VCID) after intracerebral hemorrhage (ICH). The $2,403,545 award, with a project period from August 2024 to July 2027, will identify...
This federal Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to define the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The $4,693,249 award, valid from September 17, 2024 to August 31, 2027, will support research to characterize the molecular pathways linking...
This federal Project Grant award of $2,398,590.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of brain microvascular dysfunction in cognitive impairment and dementia. The multidisciplinary research team at the University of Colorado-Denver will use a variety of experimental approaches, including animal models, native...
This Project Grant award, titled "CEREBRAL SMALL VESSEL DISEASE AND DEMENTIA: DEFINING GLOBAL RESILIENCE AND DISRUPTION IN BRAIN NETWORKS", is funded by the National Institute on Aging (CFDA 93.866 - Aging Research). The $136,778 award supports a research program led by Wake Forest University Health Sciences to investigate the impacts of cerebral microbleeds, a manifestation of small vessel disease, on brain networks and cognitive impairment. The specific objectives are to utilize...
Dr. Mark Etherton of Massachusetts General Hospital will receive $338,509.06 from the National Institute of Neurological Disorders and Stroke to study microvascular dysfunction in cerebral small vessel disease and stroke outcomes over four years from July 2021 through April 2026. This Project Grant will support research to elucidate the relationship between white matter microvascular function, ischemic tissue outcomes, and chronic microvascular dysfunction's contribution to structural injury and...
The National Institute of Neurological Disorders and Stroke (NINDS) has awarded a $604,795 Project Grant under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Northern California Institute for Research and Education, Inc. (NCIRE) to investigate the role of complement-mediated inflammation in exacerbating stroke outcomes in individuals with type 2 diabetes. The key objectives of this 5-year research project are to: 1) determine the functional role...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $422,572 to support research investigating the role of red blood cells in stroke-related hyperglycemia. The awardee, The General Hospital Corporation (doing business as Massachusetts General Hospital), will conduct a multi-year project to characterize acute...