Project Grant R01NS134819

Award Date 8/1/24
Completion Date 5/31/29
Dollars Obligated $1.3M
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Boston, MA 02114, USA
Similar Awards
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $483,480 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the role of red blood cell (RBC) bisphosphoglycerate mutase (BPGM) deficiency in contributing to cognitive impairment following ischemic stroke. The research aims to 1) use a BPGM knockout mouse...
This $454,225 Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) will support research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop new methods for assessing "effective reserve" in patients with acute ischemic stroke. The key objectives are to: 1) investigate the concept of effective reserve and its feasibility in acute ischemic stroke patients using two large...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $798,848 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on the role of skull bone marrow in post-stroke inflammation and recovery. The project aims to examine the information transfer between the central nervous system and...
This Project Grant award, titled "AGING IMMUNITY TO EXTRACELLULAR MITOCHONDRIA EXACERBATES VASCULAR COGNITIVE IMPAIRMENT AFTER STROKE", was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders. The $470,786 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) aims to investigate the role of extracellular mitochondria and...
This Project Grant award of $1,023,404.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research at the University of South Carolina to investigate the role of cerebrovascular O-GlcNAcylation in predisposing diabetics to stroke, exacerbating neurovascular injury, and impairing recovery after stroke. The research will involve in vitro studies of primary cerebral microvascular cells and in vivo studies using a high-fat...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $652,497 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on proximal upper extremity motor control and recovery after stroke. The 5-year project, starting on May 1, 2025, aims to (1) determine baseline relationships between...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $776,503 to The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of perivascular inflammation and vascular remodeling in cerebral small vessel diseases (CSVD), which can lead to intracerebral hemorrhage. The project will leverage autopsy cases and mouse...
Dr. Mark Etherton of Massachusetts General Hospital will receive $338,509.06 from the National Institute of Neurological Disorders and Stroke to study microvascular dysfunction in cerebral small vessel disease and stroke outcomes over four years from July 2021 through April 2026. This Project Grant will support research to elucidate the relationship between white matter microvascular function, ischemic tissue outcomes, and chronic microvascular dysfunction's contribution to structural injury and...
This federal Project Grant award for $853,135 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research at Dignity Health's St. Joseph's Hospital and Medical Center in Phoenix, AZ to study the role of the complement C3A receptor in exacerbating brain injury and functional impairment following ischemic stroke. The research aims to...
This federal Project Grant award, titled "Noninvasive Optical Assessment of Neuroprotection in Deep Hypothermic Circulatory Arrest Procedures", is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $630,982 award, granted on May 6, 2025 and running through February 28, 2030, supports a comprehensive study led by The General Hospital Corporation...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding a research project titled "The Role of Red Blood Cell in Stroke-Related Hyperglycemia" at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH).

The $1,267,716 award, with a project period from August 1, 2024 to May 31, 2029, aims to investigate the role of red blood cells in stroke-related hyperglycemia through translational research and mechanistic studies. Key objectives include characterizing acute hyperglycemia-related red blood cell alterations in clinical stroke patients, exploring the mechanisms of these red blood cell changes in in vitro hyperglycemic models, and validating the findings in an acute hyperglycemic stroke mouse model. The project seeks to develop a comprehensive understanding of the effects of acute hyperglycemia on red blood cells and their consequences on vascular function, with the goal of enhancing clinical care and improving patient outcomes.

Generated 7/15/25, 3:59 AM