The University of South Florida (USF) was awarded a $749,987 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The funding, with an award date of August 15, 2023, supports research to characterize the role of a novel mechanistic pathway involving fibrinogen, sphingolipids, and caveolar transcytosis during traumatic brain injury (TBI) as an example of age-related dementias and cognitive impairment. The research aims to determine how elevated fibrinogen levels enhance cerebrovascular permeability through increased caveolar protein transport, potentially contributing to short-term memory reduction, and whether inhibiting the sphingolipid synthesis pathway can ameliorate these effects. The project will utilize wild-type, hyperfibrinogenemia, and endothelium-specific gene knockout mouse models, along with advanced microscopy techniques, to investigate the underlying mechanisms. Findings from this study may unveil new therapeutic targets for vascular cognitive impairment and dementia.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $750.0k | 8/8/23 |