This Project Grant award of $580,331 from the National Eye Institute (CFDA 93.867 - Vision Research) aims to develop a deep learning-based diagnostic tool for retinopathy of prematurity (ROP), a leading cause of childhood blindness. The key products and services to be delivered under this award include: Optimizing and testing an animal-to-human (A2H) model to augment the training dataset for the deep learning-based ROP diagnostic model, using existing and newly acquired longitudinal animal ROP...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides USD 1,440,325 to the University of Oklahoma Health Sciences Center to conduct research on using surfactant protein A (SP-A) as a potential therapeutic target to prevent retinopathy of prematurity (ROP). The research aims to characterize the SP-A/chaperone/VEGF axis, confirm the SP-A receptor MYO18A, and study the impact of SP-A on endothelial cell cytoskeleton...
This Project Grant award from the National Eye Institute (NEI), under the Federal Grant Program "Vision Research" (CFDA 93.867), provides USD 462,072 to Tufts Medical Center Parent, Inc. (dba Tufts Medical Center) to study the metabolic basis of retinopathy of prematurity and potential treatments using anaplerotic substrates. The research aims to investigate fatty acid metabolic exchanges between the liver and retina, and to use anaplerotic substrates along with adeno-associated...
The National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), awarded a $770,000 Project Grant to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to support research aimed at identifying novel mechanisms and developing a new therapy for Retinopathy of Prematurity (ROP), the leading cause of preventable blindness in children. The research project, which runs from September 2024 to September 2025, will investigate the...
This Project Grant awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) funds the development and evaluation of novel surrogate augmented deep predictive learning algorithms to predict referral-warranted retinopathy of prematurity (RW-ROP). The primary goals are to: Develop algorithms that leverage early retinal images and demographic factors to accurately predict RW-ROP, enabling earlier identification of high-risk infants for close monitoring and...
This Project Grant award of $1,241,223 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research at the University of Pittsburgh to investigate the genetic and epigenetic mechanisms underlying retinal development and vision disorders. The key objectives of this 5-year research project are to: Dissect the molecular, cellular, and genomic effects of genetic mutations on retinal development using mouse models. Elucidate how transcription...
This is a Project Grant award from the National Eye Institute (NEI), part of the National Institutes of Health (NIH), under the Vision Research program (CFDA 93.867). The $451,000 award supports research by the University of Texas Southwestern Medical Center to investigate the role of the FIC enzyme in regulating the unfolded protein response (UPR) in the mammalian retina. Specifically, the project aims to determine if FIC-mediated modification of the BIP protein can modulate UPR activation,...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $1,298,882 to the University of Oklahoma Health Sciences Center to investigate the role of extracellular microRNAs (miRNAs) in mediating communication between retinal pigment epithelium (RPE) and retinal microglia cells. The primary goals are to study the transfer of miRNAs between these cell types and evaluate the use of engineered RPE-derived extracellular vesicles (EVs) as...
This federal Project Grant award of $477,109.00, provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research to determine how the transcriptional regulator PRDM13 regulates retinal development and its association with North Carolina macular dystrophy. The overarching goal is to further the understanding of mammalian retinal development by establishing the mechanisms by which PRDM13 guides cell fate decisions, and how these contribute to healthy...
This Project Grant award from the National Eye Institute (NEI), which is part of the U.S. Department of Health and Human Services, supports research to investigate the transcriptional and developmental basis of a genetic mutation associated with a rare syndrome involving congenital eye and sex development abnormalities. The $125,916 award, granted on March 1, 2025, will fund research at the University of California, Davis to characterize the genetic landscape of the mutation and its effects on...