This Project Grant awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) funds the development and evaluation of novel surrogate augmented deep predictive learning algorithms to predict referral-warranted retinopathy of prematurity (RW-ROP). The primary goals are to: Develop algorithms that leverage early retinal images and demographic factors to accurately predict RW-ROP, enabling earlier identification of high-risk infants for close monitoring and...
This Project Grant award of $745,607 from the National Eye Institute (CFDA 93.867 Vision Research) supports the development of the RETIVUE ENTIREEYE, a handheld, high-resolution, non-contact retinal screening camera for premature and healthy newborn babies. The device is designed to provide a single, wide-field retinal image to enable improved screening and early detection of retinopathy of prematurity (ROP), a leading cause of vision loss in premature infants. The 12-month commercialization...
This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $881,796 to Siloam Vision, Inc. to develop two advanced, laser-based, AI-enabled retinal imaging systems. The key innovations are: A wider field-of-view camera design that can be paired with either a scanning laser ophthalmoscope (SLO) or optical coherence tomography (OCT) system, offering 2D or 3D imaging, respectively. This aims to address an unmet need in retinopathy...
The National Eye Institute (NEI) awarded a $462,072 Project Grant (CFDA 93.867 - Vision Research) to Tufts Medical Center Parent, Inc. (Tufts Medical Center) to study the metabolic basis of retinopathy of prematurity (ROP) and investigate the potential treatment using anaplerotic substrates. The project aims to examine the fatty acid metabolic exchanges between the liver and retina, and utilize anaplerotic substrates along with adeno-associated virus-based genetic manipulations of fatty acid...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) will fund the development of a new wide-field visible-light optical coherence tomography (WF-VIS-OCT) device to evaluate the oxygen-induced retinopathy (OIR) model in rats. The $623,090 award, effective September 1, 2024, will support the Oregon Health & Science University in three main efforts: 1) developing the WF-VIS-OCT system with 5-mm transverse resolution over a...
This Project Grant award with ID R56EY036091 is funded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867). The $853,894 award supports research to investigate the mechanisms underlying placental-mediated protection against retinopathy of prematurity (ROP), a leading cause of childhood blindness. The research aims to determine how the placental LHX5 transcription factor and associated WNT signaling pathways may contribute to postnatal vascular protection despite...
The National Eye Institute (NEI) awarded a $770,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to identify novel mechanisms and develop a new therapy for retinopathy of prematurity (ROP), the leading cause of preventable blindness in children. The grant aims to: 1) investigate the therapeutic efficacy of butyrate therapy in mouse models of ROP, 2) determine the...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), is providing $306,462 to Ifocus Imaging LLC to develop a software platform called OCT-ART-DR. The platform will automate the diagnosis and staging of diabetic retinopathy using optical coherence tomography angiography (OCTA) imaging and artificial intelligence. The key products to be delivered under this award include: 1) Improved AI-based segmentation of OCTA image...
The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 - Vision Research) worth $1,440,325 to the University of Oklahoma Health Sciences Center to research targeting Surfactant Protein A (SP-A) as a novel therapeutic approach to prevent Retinopathy of Prematurity (ROP), a potentially blinding vaso-proliferative disease in prematurely born infants. The research aims to characterize the SP-A/chaperone/VEGF axis, confirm the SP-A receptor MYO18A, and study the impact of SP-A on...
This $618,600 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports research at the University of Iowa to address two key hurdles for autologous cell-based therapies for inherited retinal degenerative blindness. The first aim focuses on developing an AI algorithm to identify induced pluripotent stem cell (iPSC) lines with a propensity for efficient retinal differentiation, to avoid wasted time and resources. The second aim seeks to correlate developmental...