Project Grant R56EB040350
Award Date 9/3/26
Completion Date 9/2/27
Dollars Obligated $708K
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
- The National Institute on Aging awarded Vanderbilt University $421,250 on July 1, 2026, through the Aging Research program (CFDA 93.866) to develop a programmable RNA-based sensing circuit that targets inflammatory reactive astrocytes in Alzheimer's disease. The project engineers a single, compact RNA vector that harnesses endogenous ADAR enzymes to selectively modulate disease-driving astrocytes based on their transcriptional state. The system produces therapeutic payloads, such as...
- The National Institute of General Medical Sciences awarded Vanderbilt University $277,370 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cellular sensing and signal integration. The research program comprises three interconnected projects examining how cells perceive and integrate distinct types of biological information. Project 1 investigates crosstalk and synergy between canonical signaling pathways, identifying the...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Vanderbilt University $752,875 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the fate and function of regulatory ribosome collisions. The research constructs a high-throughput reporter library to determine the fate of disome-inducing elements—ribosome collision complexes that act as signaling hubs in protein synthesis quality control. The...
- The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University $394,915 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate and augment cholinergic signaling for enhanced neuroprosthetic performance. The research targets mechanisms that accelerate learning and control of brain-computer interfaces (BCIs) for paralyzed patients. Current intracortical neuroprosthetic implants have...
- The National Institute of General Medical Sciences awarded Vanderbilt University $435,875 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on epigenetic control of tissue regeneration across species and life stages. The award funds investigation into how gene activity is regulated to enable tissue regeneration in organisms such as planarians, teleost fish, and salamanders that retain regenerative capacity throughout their lives,...
- The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University $614,306 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular genetics of synaptic remodeling. The project examines how neural cell adhesion molecule (NCAM) and related immunoglobulin superfamily proteins regulate synaptic remodeling in developing neurons, using C. elegans DD-class GABAergic neurons as a...
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University Medical Center $393,750 on August 17, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a double saturation technique for chemical exchange saturation transfer (CEST) imaging that enhances glycogen quantification at clinical 3T MRI field strength. The funded work develops DSP-CEST, a novel quantification method that...
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University $542,947 on March 3, 2026, to develop fully non-invasive transcranial functional ultrasound imaging for adult humans under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The project applies signal processing and machine learning techniques to enhance low-velocity blood flow imaging through the skull, translating functional ultrasound...
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University Medical Center $224,080 on August 3, 2026, for research into cytokine cargo signaling from extracellular vesicles under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds exploratory research on how extracellular vesicles transport cytokines to mediate immune signaling in inflammation. The work addresses a knowledge gap in understanding how cytokines carried on or within...
- The National Institute of General Medical Sciences awarded Vanderbilt University $1.741 million on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop genetically encoded dual-visible protein tags for molecular-resolution cell imaging. The project addresses the resolution gap between light microscopy and cryo-electron tomography (cryo-ET) by engineering universal protein tags simultaneously visible under both light microscopy and electron...