Project Grant R01EB038343
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $700,000 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded August 8, 2025, with completion by July 31, 2028. This award supports the development of novel radiosynthesis methods using direct [11C]CO2 methylation for production of carbon-11...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $481,250 Project Grant from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award, effective September 1, 2025, through August 31, 2027, funds the development of an innovative radiofrequency (RF) coil array specifically designed for magnetic resonance-guided focused ultrasound (MRGFUS)...
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University Medical Center $499,651 on June 4, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a prospective head motion correction system for brain MRI using wireless NMR probes. The project addresses motion artifact in MRI, particularly in pediatric imaging, by creating a real-time motion tracking and correction...
- The National Institute of Biomedical Imaging and Bioengineering awarded The University of Texas Southwestern Medical Center $236,834 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a novel magnetic resonance spectroscopy imaging sequence for non-invasive assessment of skeletal muscle metabolites in type 2 diabetes. The project develops a metabolite cycled semi-laser localized 4D echo planar...
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University $708,389 on September 3, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to design and implement short interfering RNA (siRNA) conjugates as tools for central nervous system cell-specific gene modulation. The project focuses on developing siRNA conjugates that enable targeted gene knockdown in specific CNS cell types,...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $174,621 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cardiac magnetic resonance imaging (CMR) techniques for monitoring congenital heart disease using ultra-low field (ULF) MRI systems. The recipient will adapt CMR to an inexpensive, unshielded, open-geometry ULF MRI system and apply machine learning techniques to mitigate hardware limitations and...
- The National Institute of General Medical Sciences awarded Vanderbilt University $1.741 million on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop genetically encoded dual-visible protein tags for molecular-resolution cell imaging. The project addresses the resolution gap between light microscopy and cryo-electron tomography (cryo-ET) by engineering universal protein tags simultaneously visible under both light microscopy and electron...
- The National Institute of General Medical Sciences awarded Vanderbilt University $512,849 on August 11, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to deliver the E.M.P.O.W.E.R. (Electron Microscopy Program for Organellar Workflow Education and Research) training initiative. Vanderbilt will train twenty trainees annually in hands-on electron microscopy techniques spanning transmission electron microscopy, correlative light and electron microscopy, and 3D...
- This $481,250 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to Vanderbilt University Medical Center (VUMC) on September 1, 2024. The award supports the development of an innovative, non-invasive MRI imaging technique to assess membrane lipid properties in Alzheimer's disease (AD). The key objectives are to: 1) verify the relationship between the MRI nuclear Overhauser enhancement (NOE) signal and lipid properties using reconstituted phospholipid...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Michigan $149,264 on March 26, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop magnetic resonance fingerprinting (MRF) technology for myocardial tissue characterization in patients with cardiac implantable electronic devices. The project addresses the clinical underutilization of cardiac MRI in CIED...
The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University Medical Center $393,750 on August 17, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a double saturation technique for chemical exchange saturation transfer (CEST) imaging that enhances glycogen quantification at clinical 3T MRI field strength. The funded work develops DSP-CEST, a novel quantification method that isolates glycogen nuclear Overhauser enhancement (glycoNOE) signal at -1 ppm from water and confounding signals, addressing limitations of existing techniques such as carbon-13 magnetic resonance spectroscopy that exhibit low detection sensitivity, poor spatial resolution, and equipment constraints. The method will be incorporated into interleaved saturation and balanced steady-state free precession acquisitions, with acquisition schemes and sequence parameters optimized through simulations. Validation will occur through phantom experiments mimicking muscle tissue, animal models of Duchenne muscular dystrophy, and human leg muscle imaging following exercise. The completed method is intended to provide researchers and clinicians with a tool for investigating glycogen dynamics, muscle performance, disease assessment, and advancement of diagnosis, treatment, and drug development for glycogen-related diseases. Work is performed at Vanderbilt University Medical Center in Nashville, Tennessee, with a period of performance from August 17, 2026, through July 31, 2030. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $393.8k | 8/17/26 |