Project Grant DP2GM170993
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University $708,389 on September 3, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to design and implement short interfering RNA (siRNA) conjugates as tools for central nervous system cell-specific gene modulation. The project focuses on developing siRNA conjugates that enable targeted gene knockdown in specific CNS cell types,...
- The National Institute of General Medical Sciences awarded Vanderbilt University $277,370 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cellular sensing and signal integration. The research program comprises three interconnected projects examining how cells perceive and integrate distinct types of biological information. Project 1 investigates crosstalk and synergy between canonical signaling pathways, identifying the...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Vanderbilt University $250,000 on September 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to acquire an ASFA Spotter V6.7 HE automated liquid handling system for the Vanderbilt Institute of Chemical Biology High-Throughput Screening Core Facility. The equipment addresses a critical bottleneck in scaling organoid and other three-dimensional culture models for...
- The National Institutes of Health Office of the Director awarded Vanderbilt University $1,281,400 on May 15, 2026, under the Research Infrastructure Programs (CFDA 93.351) to acquire a LUMICKS C-TRAP DYMO300 microscope system. The instrument combines optical tweezers for exerting forces on molecules and cells with confocal imaging and single-molecule fluorescence detection capabilities, supported by a microfluidic laminar flow platform for assay construction and protocol refinement. The...
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University Medical Center $262,388 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how the RNA binding protein HNRNPA2B1 regulates macrophage responses to Mycobacterium tuberculosis infection. The research examines alternative splicing as a mechanism controlling the balance between MTB virulence and host antimicrobial defenses. The award funds work to define how...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $678,370 to ST Jude Children's Research Hospital Inc. on May 1, 2026, for research on imaging protein synthesis on the ribosome using single-molecule FRET under the Biomedical Research and Research Training program (CFDA 93.859). The funded work investigates the kinetic and structural basis of ribosomal protein synthesis, with emphasis on distinguishing...
- The National Human Genome Research Institute awarded Vanderbilt University Medical Center $437,500 on April 22, 2026, under the Human Genome Research program (CFDA 93.172) to conduct phenome-wide association studies of polygenic risk scores across multiple biobanks. The project, titled "Expanding Our Understanding of Polygenic Disease Comorbidity Structure: PRSxPheWAS," performs systematic phenome-wide association study analyses on published polygenic risk scores in the Polygenic Score...
- The National Institute of General Medical Sciences awarded Vanderbilt University $342,570 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate ubiquitin-mediated regulation of DNA repair pathway choice at persistent double-strand breaks in yeast. The research examines how ubiquitin proteases control the selection between different DNA repair mechanisms at sites of repair-associated telomere addition (SIRTAs) in budding yeast. The work...
- The National Institute of General Medical Sciences awarded Vanderbilt University $1.741 million on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop genetically encoded dual-visible protein tags for molecular-resolution cell imaging. The project addresses the resolution gap between light microscopy and cryo-electron tomography (cryo-ET) by engineering universal protein tags simultaneously visible under both light microscopy and electron...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Vanderbilt University Medical Center $711,408 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project, "Phenotypes and Endotypes of Recovery from Acute Disorders of Consciousness," pursues multimodal neurobiological prediction of recovery outcomes in...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded Vanderbilt University $752,875 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the fate and function of regulatory ribosome collisions. The research constructs a high-throughput reporter library to determine the fate of disome-inducing elements—ribosome collision complexes that act as signaling hubs in protein synthesis quality control. The project defines how disome fate is affected by disome sensors across different sequence contexts and cell types, develops a predictive framework of disome fate, and engineers disome-inducing elements as regulatory checkpoints during translation. The work addresses gaps in understanding mechanisms that allow certain disomes to persist, the outcomes they elicit, and their broader biological roles, with applications to understanding disome-mediated diseases linked to proteotoxic stress and neurodegeneration. Performance occurs at Vanderbilt University in Nashville, Tennessee, with a period of performance from September 1, 2026, through August 31, 2031. This is a Project Grant, a form of assistance funding under the Trans-NIH Research Support program, which covers awards from multiple offices in the NIH Office of the Director. Awards under this program are subject to OMB 2 CFR 200 audit requirements as implemented by 45 CFR 75.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $752.9k | 8/25/26 |