Project Grant R56EB037091
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $582,137 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop electrochemical aptamer-based sensors for long-duration, real-time molecular measurements in living tissue. The research aims to extend the in vivo operational lifespan of electrochemical aptamer-based sensors beyond their...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $381,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanoscale tools for studying membrane damage and repair and enable intracellular sensing. The project will uncover how cells detect, respond to, and repair damage to their plasma and nuclear membranes, and harness these processes for intracellular sensing. Theme 1 uses...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $1,189,496 on April 10, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop real-time, seconds-resolved measurements of amino acid homeostasis using electrochemical aptamer-based (EAB) sensors. The project will adapt EAB sensor technology—a platform invented by UCSB researchers—to measure plasma...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $125,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant K99GM162992). The award funds research into biophysical mechanisms of mechanotransduction and cell morphology, examining how cells respond and adapt to biochemical and physical environmental cues. The project focuses on mechanotransduction signaling in response to substrate material...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $445,049 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop membrane-inspired lipid nanoparticles for cell-type-specific expression of programmable RNA. The recipient will design novel lipid nanoparticle formulations to achieve precise, scalable delivery of biomolecules to specific cell types, combining bio-inspired...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $441,375 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanobiology in tissue-mimetic contexts. The recipient's research addresses how cells sense, process, and respond to mechanical signals within their microenvironment, with focus on the viscoelastic properties of the...
- The National Institute of General Medical Sciences awarded the University of California, Davis $432,417 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how linear and nonlinear mechanical forces in the extracellular matrix regulate cell metabolism through mechanotransduction pathways. The research uses induced pluripotent stem cells in both single-cell and organoid cultures within three-dimensional polymeric hydrogel systems to...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Cincinnati Sponsored Research Services Division $398,400 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop chemically-modified aptamer electrochemical sensors for ultra-sensitive biomonitoring. The research advances continuous biochemical monitoring technology to detect biomarkers at picomolar-to-nanomolar...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $158,240 under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, San Francisco on March 5, 2026, with a completion date of November 30, 2027. This Project Grant funds fundamental research investigating the mechanical properties and biological mechanisms of E-cadherin-mediated cell-cell contact formation and adherens junction development....
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the University of California, San Diego $1,111,464 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop magnetic resonance imaging methods for monitoring regulatory T cell (Treg) therapy in transplant models. The recipient will develop MRI-based approaches to track tolerogenic cell therapy fate in preclinical and ex vivo...
The National Institute of Biomedical Imaging and Bioengineering awarded The Regents of the University of California, San Francisco $592,108 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). UCSF will develop and validate stress-sensing microparticles that integrate deformable polymers and mechanomagnetic resonance nanotransducers to enable real-time monitoring of in vivo tissue mechanics with single-particle resolution. The project constructs microsensor-spheroid hybrids using nano- and microfabrication and tissue-engineering techniques to measure dynamic mechanical stress during spheroid development and structural transitions. The work then applies this technology to in vivo tumor xenograft models to dissect tumor mechanics. The research aims to identify processes to modulate cellular mechanics during developmental, physiological, and pathological processes, with potential application to other organ systems for dynamic tissue mechanics monitoring. Performance occurs in San Francisco, California. The project period runs from September 1, 2026, through August 31, 2027. This is a Project Grant assistance type supporting hypothesis-driven biomedical research within NIBIB's mission to transform disease understanding through technology development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $592.1k | 8/19/26 |