Project Grant R35GM166353
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $125,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant K99GM162992). The award funds research into biophysical mechanisms of mechanotransduction and cell morphology, examining how cells respond and adapt to biochemical and physical environmental cues. The project focuses on mechanotransduction signaling in response to substrate material...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on August 24, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research mapping the structure and functions of the endoplasmic reticulum in health and disease. The project integrates single-molecule imaging, high-speed single protein tracking, and correlative cryo-fluorescence/electron microscopy to understand how endoplasmic reticulum...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $526,805 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop episomal single-cell reporter assays for measuring the activity of hundreds to thousands of regulatory elements with tissue-specific resolution in whole developing embryos. The research focuses initially on enhancers as critical regulatory elements controlling gene expression timing and...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $445,049 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop membrane-inspired lipid nanoparticles for cell-type-specific expression of programmable RNA. The recipient will design novel lipid nanoparticle formulations to achieve precise, scalable delivery of biomolecules to specific cell types, combining bio-inspired...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $384,394 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular determinants of lipid-protein recognition through computational and experimental approaches. The research integrates deep-learning, molecular dynamics simulation, and de novo protein design to characterize biophysical interactions governing binding affinity and...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $211,433 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and biophysical principles governing protein-glycan interactions. The research program pursues three major objectives: defining the thermodynamic and structural basis of protein-glycan interactions at the atomic level to reveal how proteins achieve specificity within...
- The National Institute of General Medical Sciences awarded the University of California, Davis $672,980 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing program title) to conduct research engineering cell-cell adhesion through intercellular junction mechanisms. The research addresses the design and development of monoclonal antibodies targeting distinct cadherin conformations—strand-swap dimers and X-dimers—to engineer cell-cell...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $369,347 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct high-resolution structural analysis of megasynthases by cryo-electron microscopy. The project develops molecular tools and probes to enable structural visualization of protein-protein interactions within carrier protein-dependent biosynthetic pathways, including fatty acid synthase,...
The National Institute of General Medical Sciences awarded the University of California, San Diego $381,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanoscale tools for studying membrane damage and repair and enable intracellular sensing. The project will uncover how cells detect, respond to, and repair damage to their plasma and nuclear membranes, and harness these processes for intracellular sensing. Theme 1 uses nanoelectrodes to generate nanoscale pores and monitor their resealing in real time, defining how plasma membrane rupture size and geometry bias cells toward distinct repair mechanisms—endocytosis, exocytosis, or annexin/escrt-mediated closure. Current methods cannot reproducibly generate ruptures of defined size, timing, or location. Theme 2 investigates nuclear envelope rupture in physiological contexts using nanopillar substrates that impose defined nuclear deformations, uncovering how curvature and rupture parameters dictate repair efficiency and nuclear stability. Existing approaches lack throughput or are restricted to migrating cells. Theme 3 extends these approaches to build multiplexed nanoelectrode arrays for minimally invasive intracellular sensing, developing and validating sensors for potassium, glucose, and dopamine to establish feasibility and functionality. Current intracellular sensing methods often require cell lysis or fluorescent reporters, preventing real-time, label-free, and multiplexed measurements in intact cells. Period of performance runs from September 1, 2026, through May 31, 2031. Work is performed in La Jolla, California.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $381.2k | 8/26/26 |