Project Grant R01EB038223
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $582,137 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop electrochemical aptamer-based sensors for long-duration, real-time molecular measurements in living tissue. The research aims to extend the in vivo operational lifespan of electrochemical aptamer-based sensors beyond their...
- The National Institute of Biomedical Imaging and Bioengineering awarded North Carolina State University $1.292803 million on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop new methods for generating high-performance aptamers for in vivo monitoring of small molecules. The research aims to advance nucleic-acid-based synthetic receptors that offer advantages over antibodies for molecular sensing,...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $1,189,496 on April 10, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop real-time, seconds-resolved measurements of amino acid homeostasis using electrochemical aptamer-based (EAB) sensors. The project will adapt EAB sensor technology—a platform invented by UCSB researchers—to measure plasma...
- The National Science Foundation (NSF) awarded a three-year, $449,999 Project Grant under their Engineering program (CFDA 47.041) to the University of Cincinnati to develop an implantable biosensor platform that can continuously monitor various biomarkers in the body for over a year. The project aims to create a new class of long-lasting aptamer-based sensors protected by robust porous oxide coatings, which would enable the first practical implantable monitoring system for managing chronic...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Trustees of Boston University $245,250 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop living microbial sensors for continuous biochemical monitoring. The project will engineer and validate a self-renewing cell cartridge that maintains bacterial viability for multiple weeks using passive nutrient diffusion and...
- The National Science Foundation Division of Electrical, Communications and Cyber Systems awarded $200,000 to the University of Houston on October 1, 2026, for collaborative research developing FBEP-enabled electrochemical sensors for heart failure monitoring under the Engineering program (CFDA 47.041). The research develops a wearable sensing approach for continuous monitoring of N-terminal pro-B-type natriuretic peptide in skin interstitial fluid as an alternative to intermittent blood draws...
- The National Science Foundation Division of Electrical, Communications and Cyber Systems awarded the University of Kansas Center For Research Inc. $200,000 on October 1, 2026, under the Engineering program (CFDA 47.041) to develop electrochemical sensors for continuous heart failure monitoring. The research will engineer an aptamer-based electrochemical platform combining molecular-recognition engineering, electrically controlled sensing using fast biphasic electric pulse waveforms, and wearable...
- The National Science Foundation Division of Electrical, Communications and Cyber Systems awarded the University of Connecticut $200,000 on October 1, 2026, under the Engineering program (CFDA 47.041) to develop wearable electrochemical sensors for continuous heart failure monitoring. The project will create an aptamer-based electrochemical platform combining molecular-recognition engineering, electrically controlled sensing, and wearable microneedle technology to measure N-terminal pro-B-type...
- This National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) Federal Grant Program (CFDA 47.070) award of $1,200,000 provides funding to the University of California, Berkeley from October 1, 2024 to September 30, 2028 to develop innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics for next-generation diagnostics. The key objectives of this project grant are to: (1) develop molecular engineering techniques using DNA origami...
- The National Science Foundation Division of Chemistry awarded the University of Cincinnati Sponsored Research Services Division $662,791 on August 1, 2026, to develop a tethered entity electrochemistry system for investigating single-biomolecule behavior on surfaces using scanning electrochemical cell microscopy. The project will create a catalytic metal nanoparticle tethered to an electrode surface via a nucleic acid aptamer, designed so that the tether's collisional frequency changes when...
The National Institute of Biomedical Imaging and Bioengineering awarded the University of Cincinnati Sponsored Research Services Division $398,400 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop chemically-modified aptamer electrochemical sensors for ultra-sensitive biomonitoring. The research advances continuous biochemical monitoring technology to detect biomarkers at picomolar-to-nanomolar concentrations—a range currently inaccessible to existing sensors. The project focuses on three specific aims: developing chemically-modified aptamers for insulin, NT-proBNP, and cystatin C under interstitial fluid conditions using rapid-SELEX methods; engineering electrochemical sensors achieving greater than 100 percent signal response with 20 percent accuracy in serum for more than one week; and demonstrating in-vivo monitoring of at least one target analyte in a porcine model for one week. Current aptamer sensors detect only micromolar to millimolar analytes due to weak binding interactions; the chemical modifications add hydrophobic and π-system interactions to overcome this limitation and enable multi-day in-vivo sensing. The work is performed at Cincinnati, Ohio. The period of performance runs from September 1, 2026, through May 31, 2030. This is a Project Grant, a form of assistance funding supporting hypothesis-driven research in biomedical imaging and bioengineering technology development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $398.4k | 9/1/26 |