Project Grant R56DK141457
- This $423,890 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859). The grant is being used to support fundamental scientific research and advanced training focused on understanding the mechanisms underlying the survival and uncontrolled proliferation of stem cells with DNA damage, and the influence of surrounding tissues on stem cell behavior during tissue...
- This federal Project Grant award of $560,100 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate how environmental exposures, such as industrial pollution and catastrophic events, lead to hematopoietic stem cell dysfunction and the progression of clonal hematopoiesis. The project, awarded to the Albert Einstein College of Medicine in Bronx, NY, will...
- This $715,501.00 Project Grant awarded on March 15, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at Columbia University's Health Sciences Division. The project aims to investigate the role of T helper cells and stem cells in colon homeostasis and tumor initiation. Key objectives include determining how T cell cytokines modulate colon stem cell...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $133,333 Project Grant to Yale University to study the mechanisms underlying the myeloid bias in aged hematopoietic stem and progenitor cells (HSPCs). The research aims to correct this myeloid bias by preventing the turnover of the linker histone H1.0, which could have implications for addressing diverse...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is for the transformation of a human-induced pluripotent stem cell (iPSC)-derived bone marrow organoid to study hematopoiesis. The key objectives are to perform cellular mapping of the organoid, optimize it for the study of hematopoietic development, and culture the organoid under specific...
- This Project Grant award, valued at $801,000.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at The Children's Hospital Corporation, doing business as Boston Children's Hospital, to investigate the role of stress granules in red blood cell development, particularly during stress conditions. The research aims to uncover the...
- This federal Project Grant award of $641,794 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the mechanisms that protect beta-cells from DNA damage during periods of growth and adaptation, in order to maintain beta-cell homeostasis and prevent the loss of functional beta-cells, a key factor in the development of type 1 and type 2...
- This $3,140,632 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) aims to elucidate the mechanisms underlying human endocrine lineage commitment and harness this knowledge to improve strategies for beta cell replacement in diabetes treatment. The 4-year project, awarded to the Regents of the University of California, San Francisco, seeks to enhance the...
- This federal Project Grant award, with a total funding amount of $645,617, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is aimed at understanding the dysfunction of hematopoietic stem cells in refractory Crohn's disease, a condition that is resistant to traditional treatments. The research will profile hematopoietic stem cell populations...
- This $225,306 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project between researchers at the University of Southern California (USC) and a German partner to investigate the long-term impact of early-life growth signals on adult hematopoietic (blood) stem cell function and selection. The key products and services to be delivered under this 3-year award include: 1) using stem cell transplantation and...
This $200,000 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Baylor College of Medicine in Houston, Texas to investigate how proteostatic (protein homeostasis) stress influences the fate and function of hematopoietic stem cells (HSCs). The research aims to systematically map how specific proteostatic and metabolic stressors remodel HSC populations, generating a quantitative atlas linking proteome remodeling to preservation or loss of HSC stemness. The work will also extend these analyses to primary human CD34+ stem and progenitor cells to identify conserved stress response programs that stabilize an HSC-like state. This research is expected to provide new insights into how environmental and intrinsic cues jointly shape stem cell fate, with potential to inform strategies for improving HSC function.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.0k | 9/2/25 |