Project Grant R56DK140148

Award Date 9/7/24
Completion Date 8/31/25
Dollars Obligated $294K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Rochester, NY 14627, USA
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This federal Project Grant award of $293,604 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to understand the role of the hypothalamic adhesion G-protein coupled receptor L 1 (ADGRL1) in counteracting hypoglycemia (dangerously low blood glucose levels).

The primary research aims are to: 1) Establish the contribution of ADGRL1 in the ventromedial nucleus of the hypothalamus (VMH) to eliciting the counterregulatory response to hypoglycemia, and 2) Determine the involvement of VMH-ADGRL1 in regulating glutamatergic tone and adrenal sympathetic nerve activity in response to hypoglycemia. This research has the potential to elucidate the role of the novel glucoreceptor ADGRL1 in counteracting hypoglycemia and attenuating hypoglycemia-associated autonomic failure.

The project includes a sub-award to the University of Iowa to leverage expertise in studying the role of ADGRL1 in a neuroendocrine circuit involving the adrenal glands.

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