Project Grant K01DK143207

Award Date 6/1/25
Completion Date 3/31/30
Dollars Obligated $124K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
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This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the ANO4 calcium-activated chloride channel in the area postrema (AP) and its function in mediating the orexigenic (appetite-stimulating) actions of the hormone asprosin. The $123,908 award, effective from June 1, 2025 to March 31, 2030, will allow the researcher to:

  1. Examine the physiological functions of ANO4-expressing neurons in the AP in the context of type 1 diabetes and diet-induced obesity, including whether inhibition of ANO4 can alleviate hyperglycemia and obesity.

  2. Characterize the metabolic phenotypes of mice with deletion of the asprosin receptor PTPRD in ANO4-expressing AP neurons.

  3. Determine if ANO4 in the AP is required for asprosin's action in vivo and characterize the cellular functions of ANO4-expressing AP neurons in response to asprosin when PTPRD or ANO4 is deleted.

This research aims to reveal ANO4 in the AP as a potential target for treating obesity and associated complications, as well as further elucidate the role of ANO4 in mediating asprosin's actions on energy and glucose homeostasis.

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