Project Grant R00DK134853

Award Date 7/1/25
Completion Date 6/30/28
Dollars Obligated $249K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Boston, MA 02215, USA
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The research aims to: 1) Image cAMP dynamics in paraventricular hypothalamic neurons during feeding-induced peptide release, 2) Measure how directly increasing or decreasing cAMP alters the activity of these neurons, and 3) Engineer and use subcellularly targeted cAMP signaling tools to understand local cAMP regulation. This work is expected to fill a key knowledge gap on how cAMP signaling mediates the effects of hunger and satiety peptides on neurons that control energy balance, providing insights that could inform treatments for obesity.

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