Project Grant R01DK140148

Award Date 6/17/25
Completion Date 3/31/30
Dollars Obligated $538K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Lexington, KY 40506, USA
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This federal Project Grant award of $293,604 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to understand the role of the hypothalamic adhesion G-protein coupled receptor L 1 (ADGRL1) in counteracting hypoglycemia (dangerously low blood glucose levels). The primary research aims are to: 1) Establish the contribution of ADGRL1 in the ventromedial nucleus of the hypothalamus...
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This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to understand the role of the protein ADGRL1 in the hypothalamus and its importance for the counterregulatory response to hypoglycemia. The $538,354 award, spanning June 2025 to March 2030, will be administered by the University of Kentucky Research Foundation. The research aims to establish ADGRL1's contribution to eliciting the counterregulatory response, as well as its involvement in regulating glutamatergic tone and adrenal sympathetic nerve activity in response to hypoglycemia. This work could help elucidate the mechanisms underlying hypoglycemia-associated autonomic failure, which is a significant challenge for individuals with diabetes.

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