Project Grant R56DE034699
- The National Institute of Dental and Craniofacial Research awarded Oregon Health & Science University $429,000 on July 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate how extracellular membrane vesicles from the oral commensal bacterium Streptococcus sanguinis modulate interferon signaling in epithelial cells. The research employs biochemical, proteomic, and transcriptomic approaches to define the molecular mechanism by which a predicted...
- The National Institute of Dental and Craniofacial Research awarded Oregon Health & Science University $634,041 on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate protein interaction networks and posttranscriptional gene regulation in Streptococcus mutans, the dominant species associated with dental caries risk. The research employs a multidisciplinary approach integrating genetics, advanced mass spectrometry, next-generation sequencing,...
- The National Institute of Dental and Craniofacial Research awarded the University of Washington $623,593 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of P75 neurotrophin receptor (P75NTR) in temporomandibular joint (TMJ) cartilage homeostasis and degenerative disease. The research defines cellular and molecular mechanisms regulating TMJ cartilage health and degeneration, with the goal of developing novel therapeutic strategies...
- The National Institute of Dental and Craniofacial Research awarded Massachusetts General Hospital $408,951 on February 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, R21DE034917) to investigate photochemical tissue passivation as a treatment approach for temporomandibular joint osteoarthritis. The research applies photocrosslinking of tissue proteins—specifically collagen—through rose bengal solution and green light exposure to reduce inflammation and prevent...
- The National Institute of Dental and Craniofacial Research awarded Oregon Health & Science University $121,667 on April 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to synthesize, characterize, and validate granular hydrogel platforms for the theranostic management of periodontitis. The project develops three classes of thiolated chitosan microgel-based hydrogels: diagnostic formulations functionalized with MMP-2 and MMP-9 susceptible fluorescent peptides for...
- The National Institute of Dental and Craniofacial Research awarded Oregon Health & Science University $557,951 on August 26, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate an experimental polymicrobial abscess model system for investigating the role of microbial synergy in oral inflammatory dysbiosis. The research platform uses patient-matched human dental plaque and odontogenic abscess specimens introduced into mice to recapitulate the...
- The National Institute of Dental and Craniofacial Research awarded Colorado State University $659,747 on June 18, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to characterize the biomechanical environment of the temporomandibular joint and develop an artificial TMJ disc replacement. The research addresses advanced temporomandibular joint disorders unresponsive to conservative treatment. Current surgical practice removes the diseased disc, but this disrupts joint...
- The National Institute of Dental and Craniofacial Research awarded $1.368593 million to The Regents of the University of California, San Francisco on July 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate aberrant mechano-oxygen coupling as a driver of zinc-enriched ectopic mineralization in osteoarthritis. The research integrates complementary expertise across three principal investigators. Longitudinal studies in rats with overloaded...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Columbia University's Health Sciences Division a $655,455 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) effective September 11, 2025, with completion targeted for September 10, 2027. This R01 renewal award supports fundamental and translational research to identify temporomandibular joint (TMJ) cartilage progenitor cells and characterize their...
- The National Institute of Dental and Craniofacial Research awarded the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) $706,281 on May 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate microRNA-mediated mechanisms in temporomandibular joint health and disease. The research examines how microRNAs regulate fibrocartilage stem and progenitor cells and the Hippo signaling pathway to maintain temporomandibular joint (TMJ) health and...
The National Institute of Dental and Craniofacial Research awarded Oregon Health & Science University $900,000 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of perivascular stromal cells in temporomandibular joint osteoarthritis progression. The research examines how perivascular stem and stromal cells within the temporomandibular joint synovium regulate joint homeostasis and contribute to osteoarthritis severity, with particular focus on sex-specific differences in disease progression. The work comprises two specific aims: lineage tracing and trajectory analysis to track perivascular stromal cell activity, differentiation, and signaling pathways in a mouse model of temporomandibular joint osteoarthritis; and in vitro functional assays and multi-omic analysis to assess paracrine effects of stromal cell-derived extracellular vesicles in promoting tissue regeneration through bioactive growth factors and extracellular RNA secretion. The award is structured as a project grant with a period of performance from August 1, 2026, through July 31, 2027. Work is performed in Portland, Oregon. This is an investigator-initiated research project within NIDCR's extramural portfolio supporting basic and translational research in dental, oral, and craniofacial health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/2/26 | ||
| Not listed | $0 | 8/11/26 | ||
| Not listed | $450.0k | 7/30/26 |