Project Grant R35GM160617
- The National Institute of General Medical Sciences (NIGMS) awarded a $557,900 Project Grant to the Massachusetts Institute of Technology (MIT) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds a long-term research strategy to study ongoing adaptation and selective forces within human microbiomes. Using a culture-dependent genomic approach, the project aims to characterize within-person evolution over a dozen microbial species found in the skin, vagina,...
- This $515,926 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) will fund research to develop an in vitro gingival (gum) tissue system to study the role of microbial communities on oral health and disease. The 5-year project, beginning June 1, 2024, will be conducted by the University of Massachusetts Lowell's Office of Research Administration-Lowell. The key objectives are: (1) developing and validating a microphysiological system to study oral...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,931.00 to the University of Colorado-Denver to characterize how specialized microbial metabolites mediate interactions within the human microbiome. The research aims to elucidate the role of these metabolites in enabling microbial communities to resist antimicrobial therapies, with the goal of improving...
- This federal Project Grant award of $406,073 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research to investigate the impacts of hormonal contraceptives on fear behavior, neurocircuitry, and the gut microbiome. The goal is to improve understanding of the biological mechanisms underlying the psychiatric side effects of hormonal contraceptives, and develop strategies to identify women at risk and improve...
- This federal Project Grant award of $395,701.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to the University of Texas at Austin. The funding supports a research program to study the molecular bases of interactions between bacteria and between bacteria and their animal hosts, with a focus on insect microbiomes. The key objectives are to understand: 1) how competitive interactions between...
- The University of Massachusetts Lowell (UML) received a $540,629 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding supports a 2-year research project to study host-pathogen interactions and modulation in an in vitro model of early oral dysbiosis. The project leverages UML's expertise in developing 3D oral tissue models that mimic the native gingival environment to investigate the...
- This $382,136 Project Grant was awarded on May 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The goal of this 5-year research plan is to define the engineering principles for designing programmable bioengineered multicellular structures (probioms) in prokaryotic cells as novel probiotic-based therapeutic applications. The award supports research by the University of Maryland,...
- This federal Project Grant award of $277,380.00, provided by the Office of the Director at the U.S. Department of Health and Human Services under the Trans-NIH Research Support program (CFDA 93.310), supports the development of novel statistical methods for detecting microbiome-metabolome interactions. The research aims to create a powerful transfer-learning framework for high-dimensional regression models to uncover associations between gut microbes and their metabolites, which play a...
- This $499,996 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) will fund a research project conducted by The Pennsylvania State University to reconstruct the history of the human oral microbiome on a global scale. The project aims to understand the evolutionary mechanisms that drive changes in human microbiome diversity over time, particularly in response to shifts in geography, environment, and culture. By analyzing bacteria...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $1,759,395 Project Grant to the University of Oregon to investigate the hypothesis that "social microbiomes are major drivers of host health and sociality." The proposed research will use a zebrafish model to study how social interactions shape the microbiome, and how these "social microbiomes" impact host development, behavior,...
This federal Project Grant award of $433,125.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the role of sex hormones in influencing host-microbiome interactions in the human oral mucosa. The award will fund a 5-year project from August 1, 2025 to April 30, 2030, conducted by the University of Massachusetts Lowell. The research aims to develop a mechanistic understanding of how hormonal fluctuations, such as those associated with menstruation, pregnancy, and hormonal contraception, impact the oral microbiome and contribute to oral health and disease states. This research is expected to provide insights that can inform the development of therapeutic strategies targeting the microbiome and sex hormone signaling to address oral dysbiosis and associated conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.1k | 7/28/25 |