Project Grant R56DE034153
Award Date
9/1/24
Completion Date
8/31/25
Dollars Obligated
$491K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
Similar Awards
The Project Grant award of $628,965.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), aims to elucidate how immune cells, specifically tissue-resident macrophages, regulate salivary gland (SG) development, differentiation, and epithelial cell processes. The study leverages genetic mouse models and transcriptomic approaches to determine how macrophages govern unique cell dynamics and...
The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Program (CFDA 93.121), awarded a $1,865,330 Project Grant to the University of Alabama at Birmingham (UAB). The grant, titled "Structural and Functional Studies on the Glucosyltransferases of the Dental Caries Pathogen Streptococcus mutans," aims to determine the specific molecular mechanisms that drive the synthesis of soluble and insoluble glucans by the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Alabama at Birmingham (UAB) for $470,279 with a project period from March 2025 to February 2030. The grant supports research to identify and characterize the impact of the antimicrobial compound hypochlorous acid (HOSCN) on the growth and interactions of oral Streptococcus bacteria, including the caries-associated...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $608,632.33 to investigate the role of tuft cells in salivary gland immunity. The key objectives are to: 1) explore the distribution and function of tuft cells in salivary gland epithelium, 2) determine the chemosensory components of tuft cells, and 3) assess the effects of tuft cell ablation on salivary gland...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $656,315 to Temple University to study the impact of cyclic strain on the pathogenesis of oral microbes, particularly Candida albicans and denture-related microbiota. The goal is to mechanistically understand how biomaterial cyclic strain, driven by chewing forces, can influence the virulence and dysbiosis of oral...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate functional amyloid formation in the oral bacterium Streptococcus mutans. The total funding amount is $505,530 and the award period runs from September 16, 2024 to September 15, 2025. The key research objectives include: (1) exploring the relationships between S. mutans amyloid-forming...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $163,411.00 to The Ohio State University to study the interactions between Streptococcus mutans, a key driver of dental caries, and other commensal oral bacteria. The research aims to elucidate the nutritional niches and carbohydrate utilization preferences that allow these microbes to coexist within oral biofilms, with...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $115,992 to The Research Foundation For The State University Of New York (RF SUNY) to develop human induced pluripotent stem cell (iPSC)-derived salivary gland organoids (SGOs) with secretory function and well-defined architecture. The project aims to utilize engineered viscoelastic hydrogels to optimize the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
This $260,375 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to develop a saliva-based electrochemical assay for early detection of Sjögren's disease (SjD) and autoimmune-sicca syndrome (AI-sicca). The key objectives are to: 1) detect anti-SSA/Ro52 and anti-SSB/La autoantibodies in the saliva of SjD and AI-sicca patients using the Electric Field-Induced Release...